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To develop and apply a systematic approach to identify and define valid, relevant, and feasible measures of emergency department (ED) clinical performance. An extensive literature review was conducted to identify clinical conditions frequently treated in most EDs, and clinically relevant outcomes to evaluate these conditions. Based on this review, a set of condition—outcome pairs was defined. An expert panel was convened and a Modified‐Delphi process was used to identify specific condition—outcome pairs where the panel felt there was a link between quality of care for the condition and a specific outcome. Next, for highly rated condition—outcome pairs, specific measurable indicators were identified in the literature. The panelists rated these indicators on their relevance to ED performance and need for risk adjustment. The feasibility of calculating these indicators was determined by …