Authors
Olvert A Berkhemer, Puck SS Fransen, Debbie Beumer, Lucie A Van Den Berg, Hester F Lingsma, Albert J Yoo, Wouter J Schonewille, Jan Albert Vos, Paul J Nederkoorn, Marieke JH Wermer, Marianne AA van Walderveen, Julie Staals, Jeannette Hofmeijer, Jacques A van Oostayen, Geert J Lycklama à Nijeholt, Jelis Boiten, Patrick A Brouwer, Bart J Emmer, Sebastiaan F de Bruijn, Lukas C van Dijk, L Jaap Kappelle, Rob H Lo, Ewoud J van Dijk, Joost De Vries, Paul LM de Kort, Willem Jan J van Rooij, Jan SP van den Berg, Boudewijn AAM Van Hasselt, Leo AM Aerden, René J Dallinga, Marieke C Visser, Joseph CJ Bot, Patrick C Vroomen, Omid Eshghi, Tobien HCML Schreuder, Roel JJ Heijboer, Koos Keizer, Alexander V Tielbeek, Heleen M den Hertog, Dick G Gerrits, Renske M van den Berg-Vos, Giorgos B Karas, Ewout W Steyerberg, H Zwenneke Flach, Henk A Marquering, Marieke ES Sprengers, Sjoerd FM Jenniskens, Ludo FM Beenen, René van den Berg, Peter J Koudstaal, Wim H van Zwam, Yvo BWEM Roos, Aad van der Lugt, Robert J van Oostenbrugge, Charles BLM Majoie, Diederik WJ Dippel
Publication date
2015/1/1
Journal
New England Journal of Medicine
Volume
372
Issue
1
Pages
11-20
Publisher
Massachusetts Medical Society
Description
Background
In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of a beneficial effect on functional outcome is lacking.
Methods
We randomly assigned eligible patients to either intraarterial treatment plus usual care or usual care alone. Eligible patients had a proximal arterial occlusion in the anterior cerebral circulation that was confirmed on vessel imaging and that could be treated intraarterially within 6 hours after symptom onset. The primary outcome was the modified Rankin scale score at 90 days; this categorical scale measures functional outcome, with scores ranging from 0 (no symptoms) to 6 (death). The treatment effect was estimated with ordinal logistic regression as a common odds ratio, adjusted for prespecified prognostic factors. The adjusted common odds ratio measured the …
Scholar articles
OA Berkhemer, PSS Fransen, D Beumer… - New England Journal of Medicine, 2015