Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-α-D-glucopyranosyl-L-ascorbic acid
I Yamamoto, N Muto, K Murakami, JI Akiyama - The Journal of nutrition, 1992 - Elsevier
We evaluated the effect of 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G) on collagen
synthesis in cultured human skin fibroblasts and on proliferation of fibroblasts. At
concentrations of 0.1–0.5 mmol/L, AA-2G effectively stimulated collagen synthesis with an
effectiveness comparable to that of L-ascorbic acid. On the other hand, 6-O-α-D-
glucopyranosyl-L-ascorbic acid showed a weak effect. The stimulation of collagen synthesis
by AA-2G was attenuated by the addition of a collagen synthesis inhibitor, L-azetidine 2 …
synthesis in cultured human skin fibroblasts and on proliferation of fibroblasts. At
concentrations of 0.1–0.5 mmol/L, AA-2G effectively stimulated collagen synthesis with an
effectiveness comparable to that of L-ascorbic acid. On the other hand, 6-O-α-D-
glucopyranosyl-L-ascorbic acid showed a weak effect. The stimulation of collagen synthesis
by AA-2G was attenuated by the addition of a collagen synthesis inhibitor, L-azetidine 2 …