Alternative titles; symbols
DO: 1470;
Cytogenetic location: 15q25.3-q26.2 Genomic coordinates (GRCh38): 15:84,700,001-98,000,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 15q25.3-q26.2 | Major depressive disorder 2 | 608516 | 2 |
For a phenotypic description and a discussion of genetic heterogeneity of major depressive disorder (MDD), see 608516.
Major depressive disorder (MDD) is a multifactorial disorder with moderate heritability. Family and twin studies suggested the greatest relative risk for MDD, compared with the risk of the general population, probably is observed in families of probands with early age at onset and/or recurrent episodes. Holmans et al. (2004) performed a genome scan of families multiply affected with recurrent, early-onset MDD. The sample consisted of 297 informative families containing 415 independent affected sib pairs. Affected cases had recurrent MDD with onset before 31 years of age for probands or age 41 years for other affected relatives; the mean age of onset was 18.5 years, and the mean number of depressive episodes was 7.3. Genomewide significant linkage was observed on chromosome 15q25.3-q26.2. The linkage was not sex-specific.
Holmans, P., Zubenko, G. S., Crowe, R. R., DePaulo, J. R., Jr., Scheftner, W. A., Weissman, M. M., Zubenko, W. N., Boutelle, S., Murphy-Eberenz, K., MacKinnon, D., McInnis, M. G., Marta, D. H., Adams, P., Knowles, J. A., Gladis, M., Thomas, J., Chellis, J., Miller, E., Levinson, D. F. Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q. Am. J. Hum. Genet. 74: 1154-1167, 2004. [PubMed: 15108123] [Full Text: https://doi.org/10.1086/421333]