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Perinatal Insulin-Like Growth Factor as a Risk Factor for Autism
As early as 1988, insulin-like growth factor-1 (IGF1) and truncated IGF1 were identified in bovine colostrum. Subsequent studies, to be reviewed... -
Circulating Insulin-Like Growth Factor 1 Levels and Migraine Risk: A Mendelian Randomization Study
IntroductionPreclinical studies have indicated insulin-like growth factor 1 (IGF1) as a novel therapeutic target in the treatment of migraines. We...
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Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis
Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of bone remodelling and metabolism and have an essential role in...
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Insulin-like growth factor 1 associated with altered immune responses in preterm infants and pigs
BackgroundPreterm infants show low blood levels of insulin-like growth factor 1 (IGF-1), known to be negatively correlated with Interleukin-6 (IL-6)....
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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced...
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Activation of the insulin receptor by insulin-like growth factor 2
Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms,...
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Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes
BackgroundOptimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and...
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Analysis of serum insulin-like growth factor-1, fibroblast growth factor 23, and Klotho levels in girls with rapidly progressive central precocious puberty
To study the levels of serum insulin-like growth factor 1 (IGF-1), fibroblast growth factor 23 (FGF23), and Klotho, and to study their relationship...
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The Association Between Preoperative Insulin-Like Growth Factor 1 Levels and the Total Body Weight Loss in Women Post Laparoscopic Sleeve Gastrectomy
BackgroundDespite the well-described optimal initial clinical response of sleeve gastrectomy (SG) in the treatment of obesity, some patients do not...
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Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans by IGFALS , has a vital role...
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Insulin-like growth factor 1 receptor inhibits the proliferation of acute myeloid leukaemia cells via NK cell activation
Acute myeloid leukaemia (AML) denotes a heterogeneous category of cancers occurring within the bone marrow that are initiated by the unrestricted...
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Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats
BackgroundIn children, recombinant human growth hormone (rhGH) therapy for treatment of short stature has raised concerns of the early onset of...
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Genomic structures of insulin-like growth factor from golden pompano (Trachinotus ovatus) and their expression responses to the feed types
Golden pompano is an important aquaculture product in the coastal regions of southern China, which is highly dependent on insulin-like growth factor...
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Effects of gonadotropins, 11-ketotestosterone, and insulin-like growth factor-1 on target gene expression and growth of previtellogenic oocytes from shortfinned eels, Anguilla australis, in vitro
Pituitary gonadotropins, metabolic hormones, and sex steroids are known factors affecting the advanced stages of ovarian development in teleost fish....
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Associations between insulin-like growth factor-1 standard deviation score and overall nutritional parameters in patients with maintenance hemodialysis: a cross-sectional study
BackgroundThis study investigated the association between insulin-like growth factor-1 and nutritional status indicators in patients undergoing...
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Growth Hormone, Insulin-Like Growth Factor 1, Testosterone and Cortisol Responses to a Single Bout of Agility Ladder Exercise (ALE) in Water Polo Athletes: A Randomized Controlled Field Trial
AbstractAgility ladder exercise (ALE) is a very diverse and popular activity for athletes in different disciplines. In the water polo field, ALE is...
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Associations of Morphometric Changes of the Brain with the Levels of IGF1, a Multifunctional Growth Factor, and with Systemic Immune Parameters Reflect the Disturbances of Neuroimmune Interactions in Patients with Schizophrenia
The development of neuroimaging methods allows to obtain new data on the brain functioning to find neuroimaging patterns of psychopathological... -
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
BackgroundChildren with pregnancy-associated plasma protein-A2 ( PAPP-A2 ) mutations resulting in low levels of bioactive insulin-like growth factor-1...