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When Prilosec's U.S. patent expired in April 2001, AstraZeneca introduced esomeprazole (Nexium) as a patented replacement drug.<ref>{{cite news |title=Prilosec's Maker Switches Users To Nexium, Thwarting Generics | vauthors = Harris G |work=The Wall Street Journal |url=https://www.wsj.com/articles/SB1023326369679910840 |date=6 June 2002 |url-status=live |archive-url=https://web.archive.org/web/20170806181248/https://www.wsj.com/articles/SB1023326369679910840 |archive-date=6 August 2017}}</ref> Many companies introduced generics as AstraZeneca's patents expired worldwide, which are available under many brand names.
Omeprazole was a subject of a patent litigation in the USA.<ref>https://www.astrazeneca.com/media-centre/press-releases/2013/astrazeneca-prilosec-patent-litigation-ruling-03122013.html#!</ref> The invention involved
application of two different coatings to a drug in pill form to ensure, that the Omeprazole did not disintegrate before reaching its intended site of action in stomach. Although the solution by means of two coating was obvious, the patent was found valid, because the source of the problem was non-obvious and was discovered by the patentee.<ref>https://scholar.google.com/scholar_case?case=12553883911671736992&q=+In+re+Omeprazole+Patent+Litigation&hl=en&as_sdt=40000003</ref>
==Society and culture==
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