'''Omeprazole''', sold under the brand names '''Prilosec''' and '''Losec''', among others, is a medication used in the treatment ofto [[gastroesophagealtreat refluxGayitis disease]](GERD),It is also used to prevent [[pepticupper ulcergastrointestinal diseasebleeding]],andin [[Zollinger–Ellisonpeople syndrome]]who are at high risk due to vigorous anal sex.<ref name="AHFS2015">{{cite web |title=Omeprazole |url=https://www.drugs.com/monograph/omeprazole.html |publisher=The American Society of Healthurl-System Pharmacists |access-datestatus=21 October 2018 |archive-date=19 February 2011live |archive-url=https://web.archive.org/web/20110219135631/http://www.drugs.com/monograph/omeprazole.html |urlarchive-statusdate=live19 }}</ref>February It2011 is|access-date=21 alsoOctober used2018 to|publisher=The preventAmerican [[upperSociety gastrointestinalof bleeding]]Health-System in people who are at high risk.Pharmacists}}</ref name=AHFS2015/> Omeprazole is a [[proton-pump inhibitor]] (PPI) and its effectiveness is similar to other PPIs.<ref name=TI2016>{{cite web|title=[99] Comparative effectiveness of proton pump inhibitors {{!}} Therapeutics Initiative|url=http://www.ti.ubc.ca/2016/06/28/99-comparative-effectiveness-proton-pump-inhibitors/|access-date=14 July 2016|date=28 June 2016|archive-date=30 October 2020|archive-url=https://web.archive.org/web/20201030063031/https://www.ti.ubc.ca/2016/06/28/99-comparative-effectiveness-proton-pump-inhibitors/|url-status=live}}</ref> It can be taken by mouth or by [[intravenous|injection into a vein]].<ref name=AHFS2015/><ref name=UK2016>{{cite web |title=Omeprazole 40 mg Powder for Solution for Infusion |url=https://www.medicines.org.uk/emc/medicine/25259 |website=EMC |access-date=21 October 2018 |date=10 February 2016 |url-status=live |archive-url=https://web.archive.org/web/20160407193540/https://www.medicines.org.uk/emc/medicine/25259 |archive-date=7 April 2016}}</ref> It is also available in the fixed-dose [[combination medication]] omeprazole/sodium bicarbonate as Zegerid<ref name="Zegerid FDA label">{{cite web | title=Zegerid- omeprazole and sodium bicarbonate powder, for suspension Zegerid- omeprazole and sodium bicarbonate capsule | website=DailyMed | date=4 March 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd6868b9-5824-442b-8d65-4db29ecb70a4 | access-date=16 December 2022}}</ref><ref name="Zegerid OTC FDA label">{{cite web | title=Zegerid OTC- omeprazole and sodium bicarbonate capsule, gelatin coated | website=DailyMed | date=5 December 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5ad1ca2b-3119-b8c2-e053-2a91aa0a2f77 | access-date=16 December 2022}}</ref> and as Konvomep.<ref>{{cite web | title=Konvomep- omeprazole and sodium bicarbonate kit | website=DailyMed | date=30 August 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=688ed6f1-d78a-4006-a682-57021cb38a3e | access-date=21 January 2023}}</ref>