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[[File:Intramuscular site of adrenaline.jpg|thumb|Vastus lateralis site for intramuscular injection]]
[[File:Jext300-Autoinjektor-02 (cropped).jpg|thumb|upright=1.6|ALK Pharma Jext300, adrenaline autoinjector, without its safety cover]]
Epinephrine autoinjectors are hand-held devices carried by those who have severe allergies; the [[Epinephrine (medication)|epinephrine]] delivered by the device is an emergency treatment for [[
When anaphylaxis is suspected, epinephrine solution should be given as soon as possible as an [[intramuscular injection]], in the middle of the outer side of the thigh, which corresponds to the location of the [[vastus lateralis muscle]].<ref>{{cite web|url=https://medlineplus.gov/druginfo/meds/a603002.html|title=Epinephrine Injection|website=[[MedlinePlus]]}} Last revised 03/15/2017</ref> The injection may be repeated every 5 to 15 minutes if there is insufficient response.<ref name=EAACI2014/> A second dose is needed in 16–35% of episodes with more than two doses rarely required; in around 80% of the cases where a second dose is administered, it is by a medical professional.<ref name=EAACI2014/> It is not clear which are the people who might need a second injection at the outset.<ref name=EAACI2014/> The intramuscular route is preferred over [[Subcutaneous tissue|subcutaneous]] administration because the latter may have delayed absorption.<ref name=EAACI2014/><ref name=Epi10>{{cite journal|last=Simons|first=KJ|author2=Simons, FE|title=Epinephrine and its use in anaphylaxis: current issues|journal=Current Opinion in Allergy and Clinical Immunology|date=August 2010|volume=10|issue=4|pages=354–61|pmid=20543673|doi=10.1097/ACI.0b013e32833bc670|s2cid=205435146}}</ref> Minor adverse effects from epinephrine include [[tremor]]s, anxiety, headaches, and [[palpitation]]s.<ref name=EAACI2014/>
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