Yttrium (90Y) tacatuzumab tetraxetan: Difference between revisions

Revision as of 14:31, 29 October 2011

Yttrium (⁹⁰Y) tacatuzumab tetraxetan
Monoclonal antibody

Type	Whole antibody
Source	Humanized (from mouse)
Target	α-fetoprotein
Clinical data
ATC code	none
Identifiers
CAS Number	500784-58-7
Chemical and physical data
Formula	C₆₄₇₀H₉₉₇₁N₁₇₁₂O₂₀₀₇S₄₂⁹⁰Y
Molar mass	145 kDa
(verify)

Yttrium (⁹⁰Y) tacatuzumab tetraxetan (trade name AFP-Cide) is a humanized monoclonal antibody intended for the treatment of cancer.^[1] The antibody itself, tacatuzumab, is conjugated with tetraxetan, a chelator for yttrium-90^[2], a radioisotope which destroys the tumour cells.

References

Monoclonal antibodies for tumors

Tumor

Human	Adecatumumab^§ Amivantamab Ascrinvacumab^§ Atezolizumab Balstilimab^† Botensilimab Cixutumumab^§ Conatumumab^§ Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Flanvotumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Icrucumab^§ Lexatumumab^§ Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvacumab^§ Nivolumab^# Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pembrolizumab^# Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Sugemalimab Tarextumab^§ Tisotumab vedotin Teprotumumab^† Tovetumab^§ Vantictumab^§ Votumumab^§ Zalutumumab^†
Mouse	Abagovomab Altumomab pentetate Anatumomab mafenatox Arcitumomab Bectumomab Blinatumomab Capromab pendetide Detumomab Edrecolomab Ibritumomab tiuxetan Igovomab Lilotomab Minretumomab Mitumomab Nacolomab tafenatox Moxetumomab pasudotox Naptumomab estafenatox Oregovomab Pemtumomab^† Racotumomab Satumomab pendetide Solitomab Taplitumomab paptox Nofetumomab merpentan Pintumomab Tenatumomab Tositumomab
Chimeric	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Carotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ecromeximab^§ Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab Mirvetuximab soravtansine Rituximab^# Siltuximab Ublituximab Zolbetuximab
Humanized	Abituzumab^§ Alemtuzumab Belantamab mafodotin Bevacizumab Bivatuzumab mertansine^§ Brontictuzumab^§ Cantuzumab mertansine^§ Cantuzumab ravtansine^§ Cirmtuzumab Citatuzumab bogatox^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Denintuzumab mafodotin^§ Elotuzumab Emactuzumab Emibetuzumab^§ Enoblituzumab^§ Epcoritamab Etaracizumab^§ Farletuzumab^§ Ficlatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamicin Glofitamab Imgatuzumab^§ Inotuzumab ozogamicin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansine^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatox^† Parsatuzumab^§ Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Sofituzumab vedotin^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# (+deruxtecan / +emtansine) Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§
Rat/mouse hybrid	Catumaxomab Ertumaxomab^§
Chimeric + humanized	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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@@ Line 40: / Line 40: @@
 <!--Chemical data-->
 | chemical_formula = C<sub>6470</sub>H<sub>9971</sub>N<sub>1712</sub>O<sub>2007</sub>S<sub>42</sub><sup>90</sup>Y
 | molecular_weight = 145 [[kDa]]
 }}
-'''Yttrium (<sup>90</sup>Y) tacatuzumab tetraxetan''' (trade name '''AFP-Cide''') is a [[humanize]]d [[monoclonal antibody]] intended for the treatment of cancer.<ref>[http://www.ama-assn.org/ama1/pub/upload/mm/365/yttrium_90_tacatuz.doc Statement On A Nonproprietary Name Adopted By The USAN Counil]</ref> The antibody itself, tacatuzumab, is conjugated with a [[chelator]] for [[yttrium-90]]<ref>[http://apps.who.int/medicinedocs/documents/s14179e/s14179e.pdf WHO Drug Information]</ref>, a [[radioisotope]] which destroys the tumour cells.
+'''Yttrium (<sup>90</sup>Y) tacatuzumab tetraxetan''' (trade name '''AFP-Cide''') is a [[humanize]]d [[monoclonal antibody]] intended for the treatment of cancer.<ref>[http://www.ama-assn.org/ama1/pub/upload/mm/365/yttrium_90_tacatuz.doc Statement On A Nonproprietary Name Adopted By The USAN Counil]</ref> The antibody itself, tacatuzumab, is conjugated with [[tetraxetan]], a [[chelator]] for [[yttrium-90]]<ref>[http://apps.who.int/medicinedocs/documents/s14179e/s14179e.pdf WHO Drug Information]</ref>, a [[radioisotope]] which destroys the tumour cells.
-The chelator ("tetraxetan") is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. The antibody is attached to one of the four carboxyl groups as an [[amide]], and the other three are [[carboxylate anion]]s neutralizing the three positive charges of the yttrium ion.
 ==References==