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Protein-coding gene in the species Homo sapiens
Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene .[5] [6]
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily . This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins , also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic , pituitary , and gonadal hormone secretion, as well as growth and differentiation of various cell types.[6]
References
Further reading
Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction" . Recent Prog. Horm. Res . 56 : 417–50. doi :10.1210/rp.56.1.417 . PMID 11237224 .
Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase". Cell . 65 (6): 973–82. doi :10.1016/0092-8674(91)90549-E . PMID 1646080 . S2CID 36407277 .
Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene". Genomics . 32 (3): 358–66. doi :10.1006/geno.1996.0130 . PMID 8838799 .
Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia". Prostate . 34 (1): 34–43. doi :10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K . PMID 9428386 . S2CID 45515214 .
Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit" . J. Clin. Endocrinol. Metab . 85 (12): 4851–8. doi :10.1210/jcem.85.12.7052 . PMID 11134153 .
Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia" . Mol. Hum. Reprod . 9 (4): 199–203. doi :10.1093/molehr/gag029 . PMID 12651901 .
Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate" . Endocrinology . 144 (10): 4410–9. doi :10.1210/en.2003-0225 . PMID 12960042 .
Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein" . J. Reprod. Dev . 52 (4): 487–95. doi :10.1262/jrd.17110 . PMID 16627954 .
Type I
ALK1 (ACVRL1 )ALK2 (ACVR1A )ALK3 (BMPR1A )ALK4 (ACVR1B )ALK5 (TGFβR1 )ALK6 (BMPR1B )
Agonists: BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 15 )
Radotermin
ALK7 (ACVR1C )
Type II
TGFβR2 BMPR2 ACVR2A (ACVR2 )
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 5 , 6 , 7 , 8A , 8B , 15 (GDF9B) )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) , 9 , 11 (BMP11) , 15 )
Myostatin (GDF8)
Nodal
Radotermin
ACVR2B
Agonists: Activin (A , B , AB )
BMP (2 , 4 , 6 , 7 )
Dibotermin alfa
Eptotermin alfa
GDF (1 , 3 , 5 (BMP14) , 6 (BMP13) , 7 (BMP12) )
Myostatin (GDF8)
Nodal
Osteogenin (BMP3, BMP3A)
Radotermin
AMHR2 (AMHR )
Type III
Unsorted