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'''FK506-binding protein 4''' is a [[protein]] that in humans is encoded by the ''FKBP4'' [[gene]].<ref name="pmid1279700">{{cite journal |vauthors=Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M | title = Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 22 | pages = 10974–8 |date=Dec 1992 | pmid = 1279700 | pmc = 50465 | doi =10.1073/pnas.89.22.10974 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2288| accessdate = }}</ref> |
'''FK506-binding protein 4''' is a [[protein]] that in humans is encoded by the ''FKBP4'' [[gene]].<ref name="pmid1279700">{{cite journal |vauthors=Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M | title = Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 22 | pages = 10974–8 |date=Dec 1992 | pmid = 1279700 | pmc = 50465 | doi =10.1073/pnas.89.22.10974 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2288| accessdate = }}</ref> |
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| ⚫ | The protein encoded by this gene is a member of the [[immunophilin]] protein family, which play a role in immunoregulation and basic cellular processes involving [[protein folding]] and trafficking. This encoded protein is a cis-trans [[prolyl isomerase]] that binds to the [[immunosuppressant]]s [[FK506]] and [[rapamycin]]. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in [[B lymphocyte|B]] and [[T lymphocyte]]s. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins ([[hsp90]] and [[hsp70]]) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the [[steroid hormone receptor]]s. This protein correlates strongly with [[adeno-associated virus]] type 2 [[Vector (molecular biology)|vectors]] (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human [[gene therapy]]. This gene has been found to have multiple polyadenylation sites.<ref name="entrez"/> |
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This protein contains [[Tetratricopeptide|TPR repeats]] and has a [[PPlase domain]]. |
This protein contains [[Tetratricopeptide|TPR repeats]] and has a [[PPlase domain]]. |
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Revision as of 06:22, 4 February 2017
FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.[5][6]
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.[6]
This protein contains TPR repeats and has a PPlase domain.
Recent research suggests that FKBP52 may play a role in preventing the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting the disease before the onset of clinical symptoms.
Interactions
FKBP52 has been shown to interact with GLMN.[7][8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000004478 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030357 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Peattie DA, Harding MW, Fleming MA, DeCenzo MT, Lippke JA, Livingston DJ, Benasutti M (Dec 1992). "Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes". Proc Natl Acad Sci U S A. 89 (22): 10974–8. doi:10.1073/pnas.89.22.10974. PMC 50465. PMID 1279700.
- ^ a b "Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa".
- ^ Chambraud, B; Radanyi C; Camonis J H; Shazand K; Rajkowski K; Baulieu E E (Dec 1996). "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin". J. Biol. Chem. 271 (51). UNITED STATES: 32923–9. doi:10.1074/jbc.271.51.32923. ISSN 0021-9258. PMID 8955134.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysource=, and|laysummary=(help)CS1 maint: unflagged free DOI (link) - ^ Neye, H (Mar 2001). "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52". Regul. Pept. 97 (2–3). Netherlands: 147–52. doi:10.1016/S0167-0115(00)00206-8. ISSN 0167-0115. PMID 11164950.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysource=, and|laysummary=(help)
Further reading
External links
- FKBP52 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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