(Go: >> BACK << -|- >> HOME <<)
Jump to content

Mark Ptashne: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
add education and positions
Reverted 2 edits by Shrek9268 (talk): Unsourced
 
(15 intermediate revisions by 11 users not shown)
Line 1: Line 1:
{{Short description|American molecular biologist}}
{{Infobox scientist
{{Infobox scientist
| name = Mark Ptashne
| name = Mark Ptashne
Line 12: Line 13:
| fields = [[Molecular Biology]]
| fields = [[Molecular Biology]]
| workplaces = [[Memorial Sloan–Kettering Cancer Center]]
| workplaces = [[Memorial Sloan–Kettering Cancer Center]]
| alma_mater = [[Reed College]]<br />[[Harvard University]]<ref>http://www.markptashne.com/</ref>
| alma_mater = [[Reed College]]<br />[[Harvard University]]
| thesis_title =
| thesis_title =
| thesis_url =
| thesis_url =
Line 34: Line 35:
}}
}}


'''Mark Ptashne''' (born June 5, 1940<ref>[http://www.bookrags.com/Mark_Steven_Ptashne Bookrags.com]</ref> in [[Chicago]]) is a [[molecular biology|molecular biologist]] and [[violin]]ist. He is the Ludwig Chair of Molecular Biology at [[Memorial Sloan–Kettering Cancer Center]] in [[New York City]].
'''Mark Ptashne''' (born June 5, 1940, in [[Chicago]]) is a [[molecular biology|molecular biologist]]. He is the Ludwig Chair of Molecular Biology at [[Memorial Sloan–Kettering Cancer Center]] in [[New York City]].


He earned his undergraduate degree at [[Reed College]] in [[Portland, Oregon]] in 1961 and his PhD from Harvard in 1968, after which he joined the faculty of Harvard. He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980. In 1993 he was awarded an endowed chair, and in 1997 he left Harvard for MSK.<ref>{{cite web |title=Mark Stephen Ptashne CV |url=https://www.mskcc.org/sites/default/files/node/1522/document/ptashne-nih-format-cv2008.pdf |publisher=MSK |accessdate=30 May 2018}}</ref>
Ptashne grew up in Chicago.<ref name=NYTsaw/> He earned his undergraduate degree at [[Reed College]] in [[Portland, Oregon]] in 1961 and his PhD from Harvard in 1968, after which he joined the faculty of Harvard. He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980. In 1993 he was awarded an endowed chair, and in 1997 he left Harvard for MSK.<ref>{{cite web |title=Mark Stephen Ptashne CV |url=https://www.mskcc.org/sites/default/files/node/1522/document/ptashne-nih-format-cv2008.pdf |publisher=MSK |accessdate=30 May 2018}}</ref>


The focus of his scientific career has been [[gene regulation]].<ref name=NYTsaw/>
⚫
Ptashne was the first scientist to demonstrate specific binding between protein and DNA, and his lifelong work has been the elucidation of the molecular mechanisms of switch between [[lytic]] and [[lysogenic]] lifecyle of [[Lambda phage|bacteriophage lambda]], as well as how the yeast transcriptional activator [[Gal4 transcription factor|Gal4]] works. He was the originator of the "ball and stick" model of [[transcription factor]] function, demonstrating in bacteria and in yeast that they typically consist of separable regions that mediate DNA binding and interaction with transcriptional activators or repressors. In 1980 he cofounded [[Genetics Institute, Inc.]] with [[Thomas Maniatis]], which was acquired by [[Wyeth]] 1996.<ref>[http://www.fundinguniverse.com/company-histories/wyeth-history/ Genetics Institute, Inc. at ''History of Wyeth'']. Fundinguniverse.com, Retrieved 25.10.2012.</ref>


⚫
Ptashne was the first scientist to demonstrate specific binding between protein and DNA, and his lifelong work has been the elucidation of the molecular mechanisms of switch between [[lytic]] and [[lysogenic]] lifecyle of [[Lambda phage|bacteriophage lambda]], as well as how the yeast transcriptional activator [[Gal4 transcription factor|Gal4]] works. He was the originator of the "ball and stick" model of [[transcription factor]] function, demonstrating in bacteria and in yeast that they typically consist of separable regions that mediate DNA binding and interaction with transcriptional activators or repressors.
⚫
In 1985, he was awarded the [[Louisa Gross Horwitz Prize]] from [[Columbia University]]. He won the [[Albert Lasker Award for Basic Medical Research]] in 1997, and the [[Massry Prize]] from the [[Keck School of Medicine]], [[University of Southern California]] in 1998. He has written popular books for a wider scientific audience, including his book ''Genes and Signals''.<ref>

{{cite journal
In 1980 he cofounded [[Genetics Institute, Inc.]] with [[Thomas Maniatis]]. The founding of a company by a Harvard scientist was something new at the time, and was very controversial.<ref name=NYTsaw>{{cite news|title=Scientist at Work: Mark Ptashne; Virtuoso in Plucking Violin or Secrets of Genetic Switches |author=Hilts, PJ |work=The New York Times |date=24 February 1998 |url=https://query.nytimes.com/gst/fullpage.html?sec=health&res=9D0DE7D9173EF937A15751C0A96E958260}}</ref>
|last=Ptashne |first=M

|year=1967
⚫
In 1985, he was awarded the [[Louisa Gross Horwitz Prize]] from [[Columbia University]]. He won the [[Albert Lasker Award for Basic Medical Research]] in 1997,<ref name=NYTsaw/> and the [[Massry Prize]] from the [[Keck School of Medicine]], [[University of Southern California]] in 1998. He has written popular books for a wider scientific audience, including his book ''Genes and Signals''.
|title=Specific Binding of the λ Phage Repressor to λ DNA

|journal=[[Nature (journal)|Nature]]
;Selected works
|volume=214 |pages=232–234
;Books
|doi=10.1038/214232a0
*{{cite book |last1=Ptashne |first1=M |last2=Gann |first2=A |year=2002 |title=Genes and Signals |publisher=Cold Harbor Spring Laboratory Press |isbn=978-0-87969-633-7}}
|issue=5085
*{{cite book|last=Ptashne |first=M |year=2004 |title=A Genetic Switch: Phage Lambda Revisited |edition=3rd |publisher=Cold Harbor Spring Laboratory Press |isbn=978-0-87969-716-7}}
}}</ref><ref>
;Papers
{{cite journal
*{{cite journal |last=Ptashne |first=M |year=1967 |title=Specific Binding of the λ Phage Repressor to λ DNA |journal=Nature |volume=214 |pages=232–234|doi=10.1038/214232a0|issue=5085|pmid=6034235 |bibcode=1967Natur.214..232P |s2cid=4209094 }}
|last=Ptashne |first=M
*{{cite journal|last=Ptashne |first=M |year=1980 |title=How the λ repressor and cro work |journal=Cell |volume=19 |pages=1–11 |doi=10.1016/0092-8674(80)90383-9 |pmid=6444544|issue=1|s2cid=54281357 |display-authors=etal}}
|year=1980
⚫
* {{Cite journal | last1 = Ptashne | first1 = M. | title = Horace Judson (1931–2011) | doi = 10.1371/journal.pbio.1001104 | journal = PLOS Biology | volume = 9 | issue = 7 | pages = e1001104 | year = 2011 | pmc =3134443 | doi-access = free }}
|title=How the λ repressor and cro work
|journal=[[Cell (journal)|Cell]]
|volume=19 |pages=1–11
|doi=10.1016/0092-8674(80)90383-9
|pmid=6444544
|issue=1
|display-authors=etal}}</ref>


==References==
==References==
{{reflist}}
{{reflist}}

==Bibliography==
⚫
* {{Cite journal | last1 = Ptashne | first1 = M. | authorlink = Mark Ptashne| title = Horace Judson (1931–2011) | doi = 10.1371/journal.pbio.1001104 | journal = [[PLoS Biology]] | volume = 9 | issue = 7 | pages = e1001104 | year = 2011 | pmid = | pmc = }}
*{{cite book
|last=Ptashne |first=M
|year=2004
|title=A Genetic Switch: Phage Lambda Revisited
|edition=3rd
|publisher=Cold Harbor Spring Laboratory Press
|isbn=978-0-87969-716-7
}}
*{{cite book
|last=Ptashne |first=M
|last2=Gann |first2=A
|year=2002
|title=Genes and Signals
|publisher=Cold Harbor Spring Laboratory Press
|isbn=978-0-87969-633-7
}}
*{{cite news
|title=Scientist at Work: Mark Ptashne; Virtuoso in Plucking Violin or Secrets of Genetic Switches
|author=Hilts, PJ
|work=[[The New York Times]]
|date=24 February 1998
|url=https://query.nytimes.com/gst/fullpage.html?sec=health&res=9D0DE7D9173EF937A15751C0A96E958260
|accessdate=2009-09-28
}}


==External links==
==External links==
Line 102: Line 70:
[[Category:Living people]]
[[Category:Living people]]
[[Category:American molecular biologists]]
[[Category:American molecular biologists]]
⚫
[[Category:Jewish biologists]]
[[Category:Harvard University faculty]]
[[Category:Harvard University faculty]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:Members of the United States National Academy of Sciences]]
[[Category:1940 births]]
[[Category:1940 births]]
[[Category:Recipients of the Albert Lasker Award for Basic Medical Research]]
[[Category:Recipients of the Albert Lasker Award for Basic Medical Research]]
⚫
[[Category:Guggenheim Fellows]]
[[Category:Massry Prize recipients]]
[[Category:Massry Prize recipients]]
[[Category:Harvard University alumni]]
[[Category:Harvard University alumni]]
[[Category:Reed College alumni]]
[[Category:Reed College alumni]]
[[Category:21st-century violinists]]




Latest revision as of 15:56, 4 January 2024

Mark Ptashne
Born (1940-06-05) June 5, 1940 (age 84)
Chicago
Alma materReed College
Harvard University
AwardsNAS Award in Molecular Biology (1979)
Louisa Gross Horwitz Prize (1985)
Lasker Award (1997)
Massry Prize (1998)
Scientific career
FieldsMolecular Biology
InstitutionsMemorial Sloan–Kettering Cancer Center

Mark Ptashne (born June 5, 1940, in Chicago) is a molecular biologist. He is the Ludwig Chair of Molecular Biology at Memorial Sloan–Kettering Cancer Center in New York City.

Ptashne grew up in Chicago.[1] He earned his undergraduate degree at Reed College in Portland, Oregon in 1961 and his PhD from Harvard in 1968, after which he joined the faculty of Harvard. He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980. In 1993 he was awarded an endowed chair, and in 1997 he left Harvard for MSK.[2]

The focus of his scientific career has been gene regulation.[1]

Ptashne was the first scientist to demonstrate specific binding between protein and DNA, and his lifelong work has been the elucidation of the molecular mechanisms of switch between lytic and lysogenic lifecyle of bacteriophage lambda, as well as how the yeast transcriptional activator Gal4 works. He was the originator of the "ball and stick" model of transcription factor function, demonstrating in bacteria and in yeast that they typically consist of separable regions that mediate DNA binding and interaction with transcriptional activators or repressors.

In 1980 he cofounded Genetics Institute, Inc. with Thomas Maniatis. The founding of a company by a Harvard scientist was something new at the time, and was very controversial.[1]

In 1985, he was awarded the Louisa Gross Horwitz Prize from Columbia University. He won the Albert Lasker Award for Basic Medical Research in 1997,[1] and the Massry Prize from the Keck School of Medicine, University of Southern California in 1998. He has written popular books for a wider scientific audience, including his book Genes and Signals.

Selected works
Books
  • Ptashne, M; Gann, A (2002). Genes and Signals. Cold Harbor Spring Laboratory Press. ISBN 978-0-87969-633-7.
  • Ptashne, M (2004). A Genetic Switch: Phage Lambda Revisited (3rd ed.). Cold Harbor Spring Laboratory Press. ISBN 978-0-87969-716-7.
Papers

References[edit]

  1. ^ a b c d Hilts, PJ (24 February 1998). "Scientist at Work: Mark Ptashne; Virtuoso in Plucking Violin or Secrets of Genetic Switches". The New York Times.
  2. ^ "Mark Stephen Ptashne CV" (PDF). MSK. Retrieved 30 May 2018.

External links[edit]


Flag of United StatesScientist icon

This article about a biologist from the United States is a stub. You can help Wikipedia by expanding it.

Stub icon

This article about an American violinist or fiddler is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Mark_Ptashne&oldid=1193588633"