This document summarizes a seminar presentation on the role of garlic in managing high cholesterol. It discusses how elevated cholesterol can lead to atherosclerosis and how garlic may help lower cholesterol levels. The presentation covers an overview of garlic's composition and chemistry. It describes allicin, garlic's main bioactive compound, and its role in cholesterol reduction. The presentation also reviews garlic's potential health benefits, including antioxidant, anti-thrombotic, anti-aging, and anti-cancer effects. It concludes that garlic can significantly help manage high cholesterol based on literature reviews.
The document discusses several spices and their potential health benefits. It provides information on the phytochemicals contained in various spices like turmeric, garlic, ginger, chili peppers, and their anti-inflammatory, antioxidant, and anticancer properties based on in vitro, animal, and human studies. However, more research is still needed to better understand the biological effects of individual spices and their potential roles in cancer prevention and treatment.
This document summarizes a study that examined the histological effects of Peganum harmala seed extract on the spleen, liver enzymes, and blood parameters of albino rats. Rats were administered normal saline or 1%, 2%, or 3% doses of P. harmala extract daily for one month. Higher doses caused more severe structural changes in the spleen, including hemorrhaging, degeneration, and necrosis. The extract also significantly affected body and liver weight. Blood glucose and cholesterol decreased significantly with treatment. While some liver enzymes were affected, white and red blood cell counts remained unchanged. Histological examination showed dose-dependent damage to spleen tissue.
Comparative Effect of Daily Administration of Allium sativum and Allium cepa ...IOSR Journals
This document summarizes a study that compared the effects of daily administration of garlic and onion extracts on alloxan-induced diabetic rats. Diabetes was induced in female rats by injecting alloxan monohydrate. The diabetic rats were divided into groups that received either garlic extract, onion extract, or saline by oral administration for six weeks. Blood samples were then analyzed for glucose and other biomarkers. The results showed that both garlic and onion extracts significantly reduced serum glucose levels compared to the untreated diabetic rats, with the garlic extract proving more potent. No significant differences were found between the extracts in terms of protecting the kidneys and liver.
Metabolic effects of taurine on experimentally induced hyperlipidemia in ratsHatem elgemezy
This document summarizes a study that evaluated the effects of taurine supplementation on lipid profiles, glucose, insulin, and antioxidant enzyme activities in rats with diet-induced hyperlipidemia. Male rats were divided into four groups: a control group fed a normal diet, a hyperlipidemic group fed a high-fat diet, a high-fat diet group also given taurine supplementation, and a control group given taurine with a normal diet. Blood and tissue samples were taken at various intervals to analyze metabolic markers and antioxidant levels. The results showed that the high-fat diet increased lipids and oxidative stress markers while decreasing antioxidant enzymes, but taurine supplementation helped prevent these metabolic changes by improving antioxidant activities and cholesterol
Mechanism of action - Reducing cholesterol with plant stanol esterBenecol
Information for Healthcare professionals. Naturally occurring plant stanols are clinically proven to lower blood cholesterol. The presentation explains their mechanism of action and shows how plant stanol ester works.
Cholesterol lowering with plant stanol ester containing Benecol foods and foo...Benecol
Presentation is for healthcare professionals only. Benecol foods and food supplements with plant stanol ester are proven to lower blood cholesterol. Presentation about the scientific background of plant stanol ester and reducing blood cholesterol with it.
Gut Microbiota: The Missing Link in Obesity Induced Nonalcoholic Liver DiseaseIOSRJPBS
Background and objective: Recent research has elucidated a close association between intestinal microbiota, obesity, insulin resistance and nonalcoholic hepatic injury. Various studies have also indicated an increase in hepatic marker enzymes in obesity. Hence, this study aims to evaluate the association of gut microbiota with obesity, insulin resistance and hepatic marker enzymes. Material and Method: This case-control study was conducted during March 2015 to October 2016 At S.C.B Medical College, Cuttack, Odisha. The study included 186 subjects (86 irritable bowel syndrome patients as per the Rome III criteria and hundred matched controls). Plasma fasting glucose, serum lipid profile, hepatic marker enzymes were analysed by commercial kits adapted to automated clinical chemistry analyser and serum fasting insulin was estimated by kits adapted to Lisa Scan. Observation: Compared to controls the Irritable bowel syndrome patients had significantly higher Body mass index (20.9± 5.6 vs 30.1±0.22), Waist-hip ratio (0.9 ± 0.11 vs 1.02 ± 0.06), lipid profile, hepatic marker enzymes and insulin resistance. Conclusion: IBS patients were obese, and exhibited dyslipidemia, insulin resistance, elevated hepatic enzymes suggesting development of NAFLD.
Foods and nutrients play a very important role in normal functioning of the body. They are helpful in maintaining the health of the individual and in reducing the risk of various diseases. Worldwide acceptance of nutraceuticals formed a relation between "nutrition" and "health" and therefore the concept of "Nutraceuticals" was evolved . In recent years, a new diet health paradigm is evolving which places more emphasis on the positive aspects of diet. The new lifestyle adopted by people today has changed the basic food habits of the latter. Consumption of the junk food has increased manifold leading to a number of diseases caused due to improper nutrition. Obesity is now recognized as a global issue. Heart disease continues to be a primary cause of death in most of the developing countries worldwide, followed by cancer, osteoporosis, arthritis and many others. Consumers being frustrated with the expensive, high-tech, disease-treatment approach in the modern medicines are seeking complementary or alternative beneficial products in the form of nutraceuticals.
Nutraceuticals are the emerging class of natural products that makes the line between food and drugs to fade .Nutraceutical is the hybrid of ‘nutrition’ and ‘pharmaceutical’. Nutraceuticals, in broad, are food or part of food playing a significant role in modifying and maintaining normal physiological function that maintains healthy human beings. The principal reasons for the growth of the nutraceutical market worldwide are the current population and the health trends. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants and other different types of herbal foods.
The nutraceuticals facilitate in combating the key health complications of the century such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc. In whole, ‘nutraceutical’ has led to the new era of medicine and health, in which the food industry has become a research oriented sector.
A Consensus Review on Hepatoprotective Potential of Herbal DrugsGaurav kumar sharma
This document summarizes a review article on the hepatoprotective potential of herbal drugs. It discusses how liver disease is a major health problem and conventional drugs can have side effects. Herbal medicines from plants like Picrorhiza kurroa and Andrographis paniculata have shown promising hepatoprotective effects compared to silymarin. Several plants are described that have been studied for their hepatoprotective properties, including Abutilon indicum, Borreria articularis, and Citrus microcarpa fruit peel extract. The review evaluates the evidence for hepatoprotective effects of herbal medicines and calls for more standardized clinical trials to support their use in treating liver diseases.
The document discusses the role of oxidative stress and free radicals in the development of cancer and the potential for antioxidants to prevent cancer development through chemoprevention. It notes that antioxidants may help protect healthy cells from damage during cancer treatment and even help destroy cancer cells. The document recommends a daily supplement containing high doses of various antioxidants, vitamins, minerals, and other nutrients to both prevent and help treat cancer through reducing oxidative stress.
Weight reduction with improvement of serum lipid profile and ratios of Sesamu...lukeman Joseph Ade shittu
Development of novel natural dietary adjunct/agent with significant therapeutic effects on metabolic disease conditions such as obesity and heart disease raises concern in recent times. We studied chronic toxicity of the combined active ingredients present in the sesame leaves and their interaction on the fasting serum lipid profiles with their ratios in thirty adult male non-obese Sprague Dawley (SD) rats. Such that, both treated groups received 14.0 and 28.0 mg/kg body weight doses of aqueous leaves extract of Sesamum radiatum respectively on a daily basis via gastric gavage, while, the control received equal volume of normal saline daily for six weeks. Significant (P < 0.05) weight loss observed in the treated groups was associated with significant (P < 0.05) reductions in both serum cholesterol and triglycerides (TG). The effect on the serum lipoprotein cholesterol components and ratios were significant in a dose related manner, such that increase in HDL accompanied a corresponding decrease in both LDL and LDL/HDL ratio. In addition, to increased in TG/HDL ratio. However, no significant differences in the relative reduction level of VLDL and triglycerides in the treated groups were found compared to control. Thus, LDL/HDL ratio is significantly a better indicator than the TG/HDL ratio in assessing the impact of sesame treatment with evidence of weight loss and hypolipidaemia especially in hypertensive heart diseases.
This research article studied the anti-obesity effects of Moringa oleifera leaf extract (MEMOL) in rats fed a high-fat diet. Rats fed the high-fat diet for 49 days became obese, with increased body weight, total cholesterol, triglycerides, and lowered HDL levels. Treatment with MEMOL at doses of 200 mg/kg and 400 mg/kg for 49 days significantly reduced body weight gain, total cholesterol, triglycerides, and LDL levels in obese rats compared to those fed just the high-fat diet. MEMOL treatment also increased body temperature and lowered liver enzymes, organ weights, and blood glucose levels in obese rats. The results suggest that MEMOL has anti-ob
Variation of Major Cations and Na+K+ATPase in Erythrocytes and Its Relation B...paperpublications3
Abstract: Lacto-vegetarians, lacto-ovo-vegetarians and pesco-vegetarians are put together as vegetarians and people who consume animal products such as meat, poultry, fish, seafood at least once a week are considered as non-vegetarians. The diet is the key factor for tolerance to glucose, urea, salt retention and many enzymes. Na+K+-ATPase, an enzyme present on the surface of RBC membrane, Na+ and K+ are seen to alter with levels of urea and creatitnine, with an altered glucose level and blood pressure. Hence, this study was undertaken to analyse the above hypothesis. The objective of this cross-sectional study was to estimate the levels of serum Na+, K+ in association with erythrocyte membrane Na+-K+ATPase and the status of serum glucose, urea and creatinine in healthy vegetarians and non-vegetarians and a co-relation was done with the diet that individual has. 50 vegetarians and 50 non-vegetarians within the age group 30-40 years were selected with the help of a questionnaire and the analysis of Na+-K+ATPase in erythrocytes and Na+, K+, urea, creatinine and glucose in serum was done in these individuals. ATPase activity was measured by the method of Raccah et al. while serum glucose was estimated by Glucose Oxidase-PerOxidase’s method, urea by DiAcetyl Monoxime’s (DAM) method and creatinine by alkaline creatinine picrate. The Na+ and K+ were measured flame photometrically. Mean and standard deviation of all the serum and erythrocytic parameters were computed and compared using a paired ‘t’ test. The p value was calculated for the comparison among the two groups, i.e., non-vegetarians and vegetarians. The results obtained showed an decrease in the activity of Na+-K+ATPase with an increased Na+, glucose and urea, which was observed to be higher in non-vegetarians when compared to vegetarians. The K+ and creatinine levels did not show any change when compared with the fooding habit of these individuals. Vegetarianism is advantageous as depicted by the lower levels of glucose, urea, Na+, K+ and higher activity of Na+-K+ATPase was observed in this study when compared to the non-vegetarians who had a comparatively higher level of these values and lower activity of Na+-K+ATPase. It strengthens the notion of vegetarianism being preferred to non-vegetarianism with the other studies done on similar fooding habit.
Keywords: Vegetarians, Non-vegetarians, glucose, urea, Na+-K+ATPase.
Title: Variation of Major Cations and Na+K+ATPase in Erythrocytes and Its Relation Between the Serum Level of These Cations Along with Glucose, Urea and Creatinine in Vegetarians and Non-Vegetarians - A Cross Sectional Study
Author: Mohit Adhikary, Smita S. Sonoli
ISSN 2349-7823
International Journal of Recent Research in Life Sciences (IJRRLS)
Paper Publications
This slide deck summarizes the studies on edible fats and inflammation in humans. Saturated fat seems to mildly pro-inflammatory, omega-6 fats neutral among healthy individuals and omega-3 fats mildly anti-inflammatory. Margarine outperforms butter in terms of inflammation.
A review on liver disorders and screening models of hepatoprotective agentspharmaindexing
This document provides an overview of liver disorders and screening models for hepatoprotective agents. It discusses the functions and structure of the liver, common liver disorders including hepatitis, cirrhosis and cancer. It also describes alcohol-induced liver diseases such as fatty liver, alcoholic hepatitis and cirrhosis. The symptoms, treatment and management of alcohol-induced liver diseases are explained. Nutrition and dietary supplements that can help treat and prevent further liver damage are also mentioned.
Estudio científico de la UV demuestra los beneficios de consumir arándanos an...Emisor Digital
La investigación, realizada por las académicas de la Escuela de Nutrición y Dietética de la Universidad de Valparaíso Ximena Palma y Samanta Thomas, junto al doctor Gonzalo Cruz, del Centro de Neurobiología y Fisiopatología Integrativa (CENFI) y académico del Instituto de Fisiología de la UV, apuntó a evaluar el manejo de la glucosa posprandial (después de las comidas) y la capacidad antioxidante de los arándanos frescos.
Garlic has a long history of medicinal and culinary use. It contains compounds like allicin that have antioxidant and antimicrobial properties. The document discusses garlic's taxonomy, phytochemistry, health benefits for conditions like heart disease and cancer, and traditional uses. Garlic may lower cholesterol and blood pressure. It also shows antibacterial effects and has been used to treat infections. The document covers various garlic supplements and concludes that garlic is an important area for further research on its health applications.
The document summarizes a study on the effects of a hydroalcoholic extract of Baliospermum montanum roots on diabetic nephropathy in rats. Key findings of the study include:
1) The extract was administered orally to diabetic rats at doses of 100mg/kg and 200mg/kg for 40 days.
2) Treatment with the extract significantly reduced blood glucose, serum cholesterol, creatinine, blood urea nitrogen, and urinary albumin and total protein levels in a dose-dependent manner.
3) The results suggest that the extract exhibits significant anti-diabetic and renal protective effects, supporting its traditional use for controlling diabetes and diabetic nephropathy.
A 62-year old man presented with cerebrovascular accident secondary to hypertension. He had a history of non-compliance with antihypertensive medications and alcohol and tobacco use. He was initially unresponsive but regained consciousness after treatment. His blood pressure fluctuated above normal levels during treatment. He received nutritional counseling and was placed on an oral fluid diet, which along with medications helped control his blood pressure and recovery. At follow-up two weeks later, his health status was satisfactory with normal vital signs and anthropometric measurements. Medical nutrition therapy played an important role in his recovery from cerebrovascular accident.
Diabetes self-management involves understanding the different types of diabetes, treatment options, and applying the chronic care model. It is important for healthcare providers to empower patients by making them knowledgeable experts in managing their own condition through education, goal setting, and addressing concerns about treatments like insulin. Proper self-management can help delay or prevent diabetes complications through techniques like regular blood sugar testing and lifestyle changes.
El documento presenta información sobre una estudiante llamada Yulietl Andrade Pérez. Menciona que muestra interés en continuar preparándose realizando actividades dentro y fuera del aula, es sociable con compañeros de otros grados, y su mejor asignatura es el español. También señala que trata de cumplir con sus tareas y siempre tiene una actitud positiva.
El documento analiza la situación política y social de Venezuela. Indica que el chavismo ya no es mayoría y ha pasado de una estrategia hegemónica a una de dominación, estimulando la lucha de clases a través de la propaganda. La mayoría de los venezolanos cree que las cosas van mal en el país y rechaza las expropiaciones y la limitación de la propiedad privada, prefiriendo el diálogo entre el gobierno y la empresa privada.
El documento define el liderazgo como la influencia interpersonal ejercida en una situación para lograr objetivos a través de la comunicación. Explica que un líder efectivo es colaborador, generador de confianza y buen comunicador. También fomenta el trabajo en equipo, la responsabilidad y el desarrollo personal. Finalmente, señala que el liderazgo es importante para el éxito de cualquier organización y hay diferentes estilos como el autocrático y el democrático.
Este documento presenta una lista de 12 pinturas al óleo del artista colombiano Juan Carlos Callejas, que incluyen temas como un tamborilero, personas de paseo, una naturaleza muerta y escenas de pueblos, con títulos como "La Fiesta", "Las Meninas en el Pueblo" y "Serenata Andina".
El documento habla sobre dos estudiantes de un colegio, Elvira y Carlos, que participaron en un concurso de poesía organizado por su maestra de lengua. Carlos presentó un poema titulado "Monotonía de una vida" donde expresa sus sentimientos hacia una persona amada. Elvira también presentó un poema llamado "Las cosas que pasan" que describe situaciones cotidianas de una manera imaginativa. Ambos estudiantes recibieron premios por sus poemas en el concurso.
Miguel Hernández fue trasladado de la cárcel de Sevilla a Madrid, donde fue liberado gracias a Pablo Neruda en 1939. Sin embargo, fue delatado de nuevo en Orihuela y detenido, siendo juzgado y condenado a muerte en 1940 aunque la pena se conmutó a 30 años de prisión. Falleció en 1942 en la prisión de Alicante a causa de la tuberculosis que contrajo mientras cumplía condena.
Manual de uso del portal servicios en línea individualeszhm vril
Este manual explica cómo acceder y utilizar el portal de servicios en línea de Movistar para ver facturas electrónicas y de papel, informes de consumo, y detalles de llamadas. Describe los pasos para registrarse en el portal, navegar entre las secciones de resumen de cuenta, facturas, y reportes, e imprimir u obtener archivos de facturas y reportes.
Lady Gaga, cuyo nombre real es Stefani Joanne Angelina Germanotta, nació en Nueva York en 1986. Comenzó su carrera musical actuando en clubes de Nueva York y componiendo canciones para otros artistas. En 2008 lanzó su álbum debut "The Fame", el cual incluye los exitosos sencillos "Just Dance" y "Poker Face". Actualmente se encuentra promocionando su segundo álbum "The Fame Monster" y su gira musical "The Monster Ball Tour".
El documento habla sobre dos estudiantes de un colegio, Elvira y Carlos, que participaron en un concurso de poesía organizado por su maestra de lengua. Carlos presentó un poema titulado "Monotonía de una vida" donde expresa sus sentimientos hacia una persona amada. Elvira también presentó un poema llamado "Las cosas que pasan" que describe situaciones cotidianas de una manera imaginativa. Ambos estudiantes recibieron premios por sus poemas en el concurso.
Los planes de refuerzo educativo son propuestos por la LOE y el RD 1513/2006 para que los alumnos con dificultades puedan alcanzar los objetivos y desarrollar las competencias básicas. Los planes pueden dirigirse a alumnos que han promocionado o no y buscan atender a la diversidad del alumnado para lograr una educación de calidad. La intervención educativa debe ajustarse al nivel de desarrollo de los alumnos y utilizar un enfoque plurimetodológico que potencie la interacción ma
Este documento resume una unidad didáctica sobre los seres vivos dirigida a alumnos de 5o curso. La unidad utiliza recursos TIC e incluye actividades individuales y en grupo para identificar las características y clasificación de los seres vivos. El documento analiza la efectividad de la unidad en términos de motivación, tareas cognitivas, procesos claros y recursos de calidad.
The Gateway Economic Development Corporation of Greater Cleveland owns and operates Quicken Loans Arena and Progressive Field in downtown Cleveland. It was formed in 1990 by the city and county to finance, build, own and operate the Gateway Sports Complex. The leases with the Cleveland Cavaliers and Cleveland Indians require the teams to pay for facility operations and maintenance. Gateway is responsible for common areas, capital repairs over $500,000, and ensuring long-term maintenance of the facilities. Both arenas saw success in 2014, with the Indians hosting baseball and concerts at Progressive Field and various concerts and events filling the schedule at Quicken Loans Arena.
Importancia de las tic en el proceso educativo2Yohana Lopez
El documento describe la importancia de las tecnologías de la información y la comunicación (TIC) en el proceso educativo. Las TIC permiten transformar la experiencia cultural humana en una representación digital que puede distribuirse a gran escala sin limitaciones. En el ambiente educativo, las TIC ofrecen información actualizada, accesible las 24 horas, enriquecida con recursos multimedia e innovación, lo que hace la experiencia de aprendizaje más atractiva y significativa para los estudiantes. Sin embargo, es en las actividades que llevan a cabo profesores y estud
Este documento presenta un proyecto TIC para un centro educativo. El proyecto tiene varias líneas de acción como alfabetización digital, uso de materiales, biblioteca escolar y formación del profesorado. Los objetivos son mejorar las habilidades del alumnado y profesorado en el uso de las TIC para el aprendizaje. El proyecto se evalúa midiendo el progreso del alumnado, profesorado y proceso de integración de las TIC en la enseñanza.
El documento describe una pizarra interactiva que permite grabar vídeos en tiempo real y dibujar sobre ellos, trabajar de forma colaborativa con otros usuarios, y compartir los vídeos y lecciones creadas a través de correo electrónico, Facebook o Twitter para proporcionar retroalimentación a los estudiantes.
Este documento proporciona la logística y guía del instructor para un taller de certificación en Microsoft Word 2007. Explica los requisitos para los candidatos y la sede del instituto, los recursos disponibles como manuales y simuladores, y la metodología del taller. La metodología incluye presentaciones divididas en secciones con objetivos, ejercicios de certificación, y prácticas recomendadas para cada tema. También incluye dos prácticas de ejemplo con los objetivos cubiertos en cada una.
Este documento presenta un proyecto TIC para un centro educativo. El proyecto tiene varias líneas de acción como alfabetización digital, uso de materiales, biblioteca escolar y formación del profesorado. Los objetivos son mejorar las habilidades del alumnado y profesorado en el uso de las TIC para el aprendizaje. El proyecto se evalúa midiendo el progreso del alumnado, profesorado y proceso de integración de las TIC en la enseñanza.
Phytotherapy of Endocrine and Metabolic DisordersMarwa A.A. Fayed
This document discusses several natural products that can be used to treat obesity and hyperlipidemia. It describes appetite suppressants such as Hoodia gordonii, Citrus aurantium, and Garcinia cambogia that work by suppressing appetite. It also discusses satiety enhancers high in fiber like oat bran and apples that promote fullness. Finally, it covers herbs that interfere with fat absorption and metabolism like chitosan, foenugreek, green tea, and garlic. The document provides details on the active constituents and mechanisms of these natural anti-obesity agents.
This document describes a study that developed a herbal cocktail to prevent stroke and cerebrovascular diseases. The study investigated the effects of a high fat diet on rats and the impact of treating the rats with extracts from four herbs: Artemisia Judaica, Panax ginseng, Salvia officinalis, and Polygonum multiflorum, both individually and combined in a cocktail. The herbal cocktail significantly lowered lipid levels, oxidative stress markers, and inflammatory mediators in the blood and liver compared to a high fat diet alone. The results suggest that the herbal cocktail has anti-hyperlipidemic and antioxidant effects and may help prevent obesity-related health problems like stroke.
1. Adiponectin is a hormone produced by adipose tissue that plays an important role in glucose regulation and fatty acid catabolism. Low levels are associated with obesity, diabetes, and other insulin resistant states.
2. The document discusses the history, structure, receptors and metabolic effects of adiponectin. It acts through receptors AdipoR1/R2 to increase fatty acid oxidation and insulin sensitivity.
3. Dysregulation of adiponectin is implicated in metabolic syndrome and related conditions. Certain drugs like thiazolidinediones are shown to increase adiponectin levels and may have therapeutic potential.
Changes in Antioxidant Enzymes in Metabolic Syndrome Patients after Consumpti...science journals
Increased oxidative stress has been suggested as an early event in the development of the metabolic syndrome and, as such, might contribute to disease progression.
Antihyperglycemic and Anti-hyperlipidemic Effect of Herbamed, A Herbal Formul...CrimsonPublishersIOD
This study evaluated the anti-diabetic effects of an herbal formulation called "Herbamed" in alloxan-induced diabetic rats. Herbamed contains extracts of 4 plants - Vernonia amygdalina, Ocimum gratissimum, Zingiber officinale, and Allium sativum. Rats were made diabetic using alloxan injections. Treatment with Herbamed at 2 doses for 7 days significantly reduced blood glucose levels and improved lipid profiles in diabetic rats in a dose-dependent manner. The effects were comparable to the anti-diabetic drug metformin. The study suggests Herbamed has anti-hyperglycemic and anti-hyperlipidemic properties, supporting its
This document summarizes a study that investigated the phytochemical composition of Cassia alata leaf extract and its effect on the histology of the pancreas in diabetic rats. Twenty-four rats were divided into diabetic and non-diabetic groups and treated with Cassia alata extract, insulin or saline for 28 days. Results showed Cassia alata contains phytochemicals like saponins, flavonoids, tannins, oxalate and alkaloids. It reduced blood sugar in diabetic rats, regenerated destroyed pancreatic islet cells, and may potentiate beta cell regeneration through its phytochemical composition.
Effect of aqueous extract of phaseolus vulgaris l. (red kidney beans) on allo...IJSIT Editor
Aqueous extract of Phaseolus Vulgaris L. (Red Kidney Beans) was investigated for its effects in
alloxan induced-diabetic rats. Twenty four albino rats were randomly allocated into four groups (A-D) of six
rats each such that group A (diabetes control) received 0.5 mL distilled water, group B (diabetes) received
400 mg/kg bwt of extract, group C (normal control) received 0.5 mL of distilled water while group D (normal)
received 400 mg/kg bwt of extract, all extract were orally administered once daily for 14 days. Diabetes was
induced in groups A&B by single interperitonial injection of 150 mg/kg alloxan monohydrate. Phytochemical
screening indicated the presence of alkaloids, balsam, flavonoids, saponins, tannins, cyanogenic glycosides,
terpenes and steroids. The hypoglyceamic potential of Phasoelus vulgaris L. was expressed in diabetes
treated rats. Blood glucose, total protein, albumin and cholesterol levels of the diabetes treated rats and
normal treated rats were not significantly (p>0.05) altered when compared with the control rats. However,
these values were significantly (p<0.05)><0.05)>0.05) effects on PCV and Hb in all groups when compared to the normal control. The study showed that
the aqueous extract of Phasoelus vulgaris L. leaves possess hypoglycaemic, antidiabetic properties and
ameliorating the high levels of marker enzymes observed in diabetes untreated rats.
This document provides information about the Biomed newsletter from Adichunchanagiri Institute of Medical Sciences. It includes the editorial board members and details about the second issue of Biomed from July 2012. The newsletter aims to keep pace with trends in biochemistry and provide valuable information to readers. It thanks the principal for support and encourages readers to provide suggestions. A picture shows members of the Department of Biochemistry.
This document summarizes a study that investigated the effects of administering aqueous extracts of white grub and white grub waste to diabetic rats over two weeks. Key findings include:
1) After the first week, the extract-treated groups showed significant reductions in several liver enzyme and protein levels compared to the untreated diabetic group. Renal parameters were also significantly lower in the extract-treated groups.
2) After the second week, the extract-treated groups continued to show significant reductions in most liver enzymes and proteins compared to the untreated diabetic group. One extract provided more benefits than the other.
3) For renal parameters after two weeks, one extract-treated group showed significantly lower levels of parameters like urea and electroly
Effect of Aqueous Administration of White Grub and Waste Extract on the Level...BRNSS Publication Hub
Introduction: The liver plays a major role in the regulation of carbohydrate metabolism, as it uses glucose as a fuel and kidneys are to excrete metabolic waste products as well as to maintain water, pH, electrolyte balance, production of calcitriol, and hemopoietin. Aim: This study aims to investigate the effect of the administration of white grub and waste on liver and kidney indices on diabetic rats. Materials and Methods: The rats were induced with diabetes by alloxanization and treated with the extracts of white grub and waste for 2 weeks. A total of 25 rats used, were randomly distributed into five groups (G1-G5) each with five rats. G1 served as normal control. G2-G5 served as diabetic control. At the end of the 1st week of extract administration, two animals from each group were randomly selected and sacrificed. At the end of the 2nd week, the remaining three animals from each group were also sacrificed and serum was collected for the determination of liver function indices (serum alkaline phosphatase [ALP], alanine aminotransferase [ALT], aspartate aminotransferase [AST] total bilirubin [TB], direct bilirubin [DB], total protein [TP], albumin [ALB], and globulin [GLB]) and kidney function parameters (urea, creatinine, and electrolyte [sodium “Na,” potassium “K,” bicarbonate “HCO3,” and chloride “Cl”]). Results: After the 1st week, the extract-treated group (G4 and G5) showed significant reductions of ALP, ALT, AST, TP, GLB, and ALB while TB and DB have normal value compared to diabetic untreated group and for renal function (G4 and G5) showed significantly lower levels of urea, Na, K, HCO3, creatinine, and Cl. After the 2nd week, the extract-treated group showed significant reductions of ALP, ALT, AST, DB, TP, ALB, and TB with significant increased levels of GLB and TP compared to diabetic untreated group (G2). G4 (extract treated) showed significantly (P < 0.05) lower levels of urea, Na, Cl, HCO3, and creatinine and with significant increased K levels compared to G2. G5 also extract-treated group indicates significant lower levels of urea, Cl, Na, and HCO3 and higher levels of creatinine and K compared to G2. Conclusion: These results suggest that the administration of aqueous extract of white grub and waste did not have any adverse effect on the liver and kidney functions in diabetic rats. The extracts have positive effect which showed that G4 (treated with whole white grub [WG]) is more effective compared to G5 (treated with WG waste).
This study investigated the effects of administering aqueous extracts of white grub and its waste on liver and kidney function in diabetic rats. Rats were induced with diabetes and treated with the extracts or a diabetes drug for 2 weeks. After both 1 week and 2 weeks of treatment:
- Liver enzymes and proteins were significantly lower in extract-treated groups compared to untreated diabetic rats, indicating protective effects on the liver.
- Kidney parameters like urea and electrolytes were also significantly lower in extract-treated groups, showing renal protection.
- The whole white grub extract seemed to have slightly better effects than the waste extract alone.
- Both extracts appeared to have positive impacts on liver and kidney function in diabetic rats
Nutraceutical and functional food:as a remedy for chronical diseasesAayush Wadhwa
A thorough presentation for reference only. I have discussed detailed mechanisms and processes of various food components in diet and how they are associated with chronical diseses
Antihyperlipidemic Activity of Torbangun Extract (Coleus amboinicus Lour) on ...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Comparative Study of The Antioxidant Activities of Monodora Myristica And A. ...iosrjce
IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB) covers studies of the chemical processes in living organisms, structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules, chemical properties of important biological molecules, like proteins, in particular the chemistry of enzyme-catalyzed reactions, genetic code (DNA, RNA), protein synthesis, cell membrane transport, and signal transduction. IOSR-JBB is privileged to focus on a wide range of biotechnology as well as high quality articles on genetic engineering, cell and tissue culture technologies, genetics, microbiology, molecular biology, biochemistry, embryology, cell biology, chemical engineering, bioprocess engineering, information technology, biorobotics.
Effect of Piper crocatum Extract Against Weight Loss and Liver Enzyme Levels ...iosrphr_editor
Piper crocatum is one of Indonesian medicinal plant that contain flavonoids, tannins, alkaloids, and saponins. Aims of this study were to evaluate the effect of Piper crocatum aqueous extract against a decrease in body weight (BW) and the activity of enzymes involved in lipid metabolism (AMPK, ACC, FAS) in liver obese rats. This study used four groups of Sprague dawley rat (n = 6), including normal group (N), obese controls (OC), Piper crocatum extract dose 1260 mg/kgBW (PcA), and Piper crocatum extract dose of 1890 mg/kgBW (PcB). Measurement of metabolic liver enzyme levels (AMPK, ACC, FAS) are using ELISA kit (CusabioTM). Results of this study showed that the PcA group produce the highest reduction in body weight (4.52%), and the lowest levels of ACC (9.13 ng/g) and FAS (360.68 ng/g) which was significantly different from obese control group (95% CI). Piper crocatum extract can't activate AMPK. The highest levels in rat liver AMPK is in N group with 8.42 ng/g, but this value is not significantly different from other groups.
Every year more than 1.5 million people are affected new cancer cases in US. According to Jaganath (2008), 56.5 million people dead annually due to chronic degenerative disease. 220 million people are affected with diabetes in the world (WHO 2011) and it will be more than 350 million by 2030 (WHO 2003). Total healthcare cost of diabetes is US$5621 per person in developed countries, US$356 in developing countries and $160 in Bangladesh (Islam et al., 2017).
So, what will be our strategy to get rid of this?
Fruits and vegetables are rich sources of a wide range of vital micronutrients, vitamins (provitamin A carotenoids, vitamin C, and folate), phytochemicals (non - provitamin A carotenoids and polyphenols), and fiber (Amiot and Lairon, 2010 ). These components with a wide range of chemical structures and functionality provide different beneficial effects beyond simple nutrition, resulting in improved health. In general, fruits and vegetables are generally low - energy foods because of a high proportion of nondigestible carbohydrate polymers such as cellulose and pectin and lower levels of proteins and lipids. Thus, fruits and vegetables supplement the high - energy foods in diet and can be seen to provide a balance in the transit of food through the gastrointestinal tract (GIT), as well as to aid digestion and subsequent action by the gut microflora in the large intestine. The influence of fruit and vegetable components (prebiotics) in intestinal health, through viscosity modification of foods during their transition through the GIT, immunity modulation, prevention of inflammation, and maintenance of an ideal population of microflora (probiotics) is continuously being unraveled.
Antioxidant and protective effect of latex of Calotropis proceraRaman Sehgal
The document summarizes a study that evaluated the antioxidant and anti-diabetic effects of latex from the Calotropis procera plant against alloxan-induced diabetes in rats. The study found that daily oral administration of the latex at 100 and 400 mg/kg doses produced a dose-dependent decrease in blood glucose levels and increase in hepatic glycogen content in diabetic rats. It also prevented loss of body weight and reduced water consumption compared to diabetic controls. The latex treatment increased hepatic antioxidant levels like superoxide dismutase, catalase and glutathione, while decreasing lipid peroxidation levels. The antioxidant and anti-diabetic effects of the latex were comparable to the standard drug glibenclamide.
The document summarizes a study on the antidiabetic activity of Aegle marmelos leaves. The study involved inducing diabetes in rats using alloxan monohydrate. The rats were then divided into several groups, including a control group, diabetic group, group receiving A. marmelos extract, and group receiving the antidiabetic drug glibenclamide. Various biochemical parameters were measured and statistically analyzed after 20 days of treatment. The results suggest that A. marmelos extract was effective in managing diabetes, lowering blood glucose and improving other biochemical parameters in diabetic rats.
Heart diseases due to hyperlipidemia (primary or secondary) can lead to cause chest pain, heart attacks,
strokes, cardiac arrhythmias, cardiac failure. Because of these risks, treatment is often recommended for people with
hyperlipidemia, because it is well known factor to increase incidence of heart diseases. This may lead to
development of atherosclerotic plaques which is major etiological factor for establishing coronary artery disease
(CAD). Hypolipidemic drugs used in allopathy include Statins, Fibric acids, Niacin, and Resins but all have their
low compliance due to frequent side effects. Medicinal herbs like Onion and Ginger are hypolipidemic agents
commonly used as flavoring agents and making foods spicy and tasty. We have compared hypolipidemic potential
between these two medicinal herbs. The study was conducted at Ghurki Trust teaching hospital, Lahore from
January to June 2018. Eighty secondary hyperlipidemic patients were enrolled after getting written consent which
was approved by Ethics committee of the hospital. They were divided in two equal groups comprising 40 patients in
each group. Group-I was treated by Ginger 10 grams daily in three divided doses for 2 months. Group-II was
advised to take Onion 200 grams daily in divided amount with each meal i.e.; breakfast, lunch, and dinner for two
months. After two months therapy it was observed by statistical analysis that 10 grams ginger reduced TC (total
cholesterol) of 38 hyperlipidemic patients 12.4 gm/dl and LDL-C (low density lipoprotein cholesterol) 27.3 mg/dl.
In group-II, onion reduced TC in 35 patients 17.9 mg/dl and LDL-C 14.8 mg/dl. Changes in tested parameters are
significant biostatistically with p-values <0.01 to <0.001. We concluded from this research work that Onion and
Ginger reduces risk of CAD by decreasing plasma total cholesterol and LDL cholesterol.
Similar to Ihekuna linda.c seminar presentation (20)
The Revolutionary Nature of Needleless Double Transfer Spikes in HealthcareNanchang Kindly Meditech
It's likely that you have witnessed medical personnel using needles to transmit fluids or medicines if you have ever visited a hospital or other healthcare facility. But as technology advances, needleless double transfer spikes are becoming more and more common and revolutionizing the delivery of healthcare.
Subcutaneous nodules in rheumatic diseases Ahmed Yehia Assistant Professor of internal Medicine, Immunology, rheumatology and allergy
How to use subcutaneous nodules as a clue for diagnosis by completing the puzzle
Hemodialysis: Chapter 11, Venous Catheter - Basics, Insertion, Use and Care -...NephroTube - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/QeWTw_fYPlA
- Video recording of this lecture in Arabic language: https://youtu.be/fUWI9boFc7w
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
STRATEGIES FOR RATIONALISING/REDUCING CAESAREAN SECTION RATE BY USE OF "SION ...Niranjan Chavan
The journey to reduce/rationalise the C-section rate started in June 2023 and it’s an ongoing study been carried out at #SionHospital #LTMMC Mumbai.
It’s going to revolutionise the journey of motherhood for safer, predictable maternal and fetal outcome.
The SION model is a structured and networked approach to promoting vaginal deliveries.
By integrating education, support, policy implementation, and continuous improvement, it aims to enhance maternity care and reduce unnecessary C-sections through collaborative efforts among healthcare providers and patients.
Encouraging trials of labor after previous C-sections (TOLAC) and fostering a multidisciplinary team approach in maternity care are crucial.
Regular training for healthcare providers and establishing supportive hospital policies further promote vaginal births.
Interventional radiology is a medical specialty that uses imaging techniques, such as X-rays, CT scans, and ultrasound, to guide minimally invasive procedures to diagnose and treat a variety of conditions. These procedures can be an alternative to open surgery, often resulting in shorter recovery times for patients.
Regenerative Medicine in Chronic Pain ManagementReza Aminnejad
Regenerative technologies are the future of medicine. The current clinical strategy focuses primarily on treating the symptoms but regenerative medicine seeks to replace tissue or organs that have been damaged by age, disease, trauma, or congenital issues.
These lecture slides, by Dr Sidra Arshad, offer a simplified description of the physiology of insulin and glucagon.
Learning objectives:
1. Describe the synthesis and release of insulin
2. Explain the mechanism of action of insulin
3. Discuss the metabolic functions of insulin
4. Elucidate the effects of insulin on adipose tissue, skeletal muscle, and liver
5. Enlist the factors which stimulate and inhibit the release of insulin
6. Explain the mechanism of action of glucagon
7. Discuss the metabolic functions of glucagon
8. Elucidate the role of insulin and glucagon in glucose homeostasis during the fasting and fed states
9. Discuss the role of other hormones in the glucose homeostasis
10. Differentiate between the types of diabetes mellitus
11. Explain the pathophysiology of the features of diabetes mellitus
12. Discuss the complications of diabetes mellitus
13. Explain the rationale of oral hypoglycemic drugs
14. Describe the features of hyperinsulinemia
Study Resources:
1. Chapter 79, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 24, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 39, Berne and Levy Physiology, 7th edition
4. Chapter 19, Human Physiology, From Cells to Systems by Lauralee Sherwood, 9th edition
5. Chapter 3, Endocrine and Reproductive Physiology, Bruce A. White and Susan P. Porterfield, 4th edition
6. Insulin and Insulin Resistance, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204764/
7. Complications of diabetes mellitus,
https://pdb101.rcsb.org/global-health/diabetes-mellitus/monitoring/complications
कायाकल्प क्लिनिक: पटना के अग्रणी सेक्सोलॉजिस्ट और स्किन केयर विशेषज्ञ
पटना का एक शानदार स्वास्थ्य सेवा प्रदाता, कायाकल्प क्लिनिक, आपके स्वास्थ्य और त्वचा की देखभाल में विशेषज्ञता प्रदान करता है। हमारे नवीनतम तकनीकी समाधानों और अनुभवी विशेषज्ञों के साथ, हम पुरुष और महिलाओं के स्वास्थ्य सम्बंधित मुद्दों को हल करते हैं। यहां पर हम प्रदान करते हैं:
Expert Treatment for Sex Issues at Kaya Kalp Clinic in Patna -best sexologist in patna
Dealing with sex-related problems? Find effective solutions at Kaya Kalp Clinic in Patna. Our experienced sexologist doctors are here to help.
Experienced Doctors
At Kaya Kalp Clinic, our team has years of experience in sexology. We’re known for successfully treating patients across India. Our certified doctors ensure expert care and support.
Comprehensive Care
We offer solutions for all kinds of sex-related issues. Our clinic is equipped with advanced equipment to ensure gentle treatment and positive results.
Patient-Focused Approach
We understand the sensitivity of these issues. Our doctors provide confidential and respectful care. We tailor treatments to meet your needs and lifestyle.
Convenient Location
Located in Patna, our clinic is easy to reach. Whether you’re searching “Sexologist Doctor Near Me” or referred by a doctor, we’re here to help.
Start Your Journey to Better Health
Don’t let sex-related issues affect your life. Contact Kaya Kalp Clinic today for expert care and support. Rediscover confidence and happiness in your sexual health.
Phone: 93342 00215
Discover the Best Sexologist in Patna: Expert Care at Kayakalp Clinic
Kayakalp Clinic - Best Sexologist in Patna
Kayakalp Clinic - Best Sexologist in Patna
When it comes to sexual health, finding the right expert is essential for effective diagnosis and treatment. At Kayakalp Clinic in Patna, we pride ourselves on providing exceptional care for a wide range of sexual health issues. If you’re searching for the best sexologist in Patna, look no further. Our team of highly skilled professionals is here to help you navigate and resolve your concerns with confidentiality and compassion.
Why Choose Kayakalp Clinic?
1. Experienced Professionals
Our sexologists are highly trained and experienced in dealing with various sexual health issues. They stay updated with the latest advancements in the field to provide the best care possible.
2. Comprehensive Services
At Kayakalp Clinic, we offer a wide range of services, including:
- Treatment for erectile dysfunction
- Solutions for premature ejaculation
- Counseling for low libido
- Infertility treatment
- Management of sexual pain disorders
- STI screening and treatment
- Relationship and intimacy counseling
3. Personalized Treatment Plans
We understand that every individual is unique, and so are their health concerns. Our sexologists take the time to understand your specific needs and create personalized treatment plans to ensure the best outcomes.
Human blood has a hydrogen ion concentration [H+ ] of 35 to 45 nmol/L and it is essential that its concentration is maintained within this narrow range.
Hydrogen ions are nothing but protons which can bind to proteins and alter their characteristics.
All the enzymes present in the body are proteins and an alteration in these enzyme systems can change the homeostatic mechanisms of the body.
Hence, a disturbance in acid-base balance can result in malfunction of the various organ systems.
The normal pH of blood is 7.35-7.45.
Acidosis is defined as a pH Less than 7.35.
Conversely, when the pH is more than 7.45, alkalosis is said to exist.
Acidosis and alkalosis are of two types each: respiratory and metabolic.
An increase in carbon dioxide (CO2 ) levels increases the plasma [H+ ] and decreases the pH (respiratory acidosis).
Similarly, a decrease in plasma carbon dioxide levels reduces the [H+ ] and increases the pH (respiratory alkalosis).
A decrease in [HC03 -] reduces the pH and is called metabolic acidosis.
Similarly, an increase in [HC03 -] increases the pH and produces metabolic alkalosis.
The pH is regulated in the human body mainly by two organs: the respiratory system and the renal system.
The arterial carbon dioxide levels are regulated by the respiratory system.
Any increase in carbon dioxide levels stimulates the respiratory centre in the medulla thus augmenting respiration, alveolar ventilation and elimination of extra CO2 levels.
A decrease in CO2 levels may reduce the stimulus to breathe and cause hypoventilation.
This response is limited by hypoxia as the hypoxic drive stimulates the patient to maintain respiration.
Respiratory response to changes in CO2 level occurs very fast.
The plasma bicarbonate levels are regulated by the kidneys.
Any decrease in [HC03 -] stimulates the kidney to retain and synthesise bicarbonate.
High [HC03 -] results in elimination of more bicarbonate in urine.
In general, the pulmonary response to a change in acid-base status is faster and occurs immediately.
However, renal regulation takes time, a few hours to days.
Kidneys filter and reabsorb all the bicarbonate in the urine.
When necessary, kidneys can also produce extra bicarbonate through the glutamine pathway.
When an acid-base disorder occurs, the initial disturbance that occurs is termed the primary disorder.
The body attempts to normaliZe the pH by certain compensatory mechanisms resulting in a secondary disorder, e.g. primary metabolic acidosis results in an increase in hydrogen ions and a consequent decrease in bicarbonate ions.
To compensate for this, the patient hyperventilates and reduces the arterial carbon dioxide levels, thus moving the pH back to normal ( compensatory respiratory alkalosis )
General Endocrinology and mechanism of action of hormonesMedicoseAcademics
This presentation, given by Dr. Faiza, Assistant Professor of Physiology, delves into the foundational concepts of general endocrinology. It covers the various types of chemical messengers in the body, including neuroendocrine hormones, neurotransmitters, cytokines, and traditional hormones. Dr. Faiza explains how these messengers are secreted and their modes of action, distinguishing between autocrine, paracrine, and endocrine effects.
The presentation provides detailed examples of glands and specialized cells involved in hormone secretion, such as the pituitary gland, pancreas, parathyroid gland, adrenal medulla, thyroid gland, adrenal cortex, ovaries, and testis. It outlines the special features of hormones, differentiating between peptides and proteins based on their amino acid composition.
Key principles of endocrinology are discussed, including hormone secretion in response to stimuli, the duration of hormone action, hormone concentrations in the blood, and secretion rates. Dr. Faiza highlights the importance of feedback control in hormone secretion, the occurrence of hormonal surges due to positive feedback, and the role of the suprachiasmatic nucleus (SCN) of the hypothalamus as the master clock regulating rhythmic patterns in biological clocks of neuroendocrine cells and endocrine glands.
The presentation also addresses the metabolic clearance of hormones from the blood, explaining the mechanisms involved, such as metabolic destruction by tissues, binding with tissues, and excretion by the liver and kidneys. The differences in half-life between hydrophilic and hydrophobic hormones are explored.
The mechanism of hormone action is thoroughly covered, detailing hormone receptors located on the cell membrane, in the cell cytoplasm, and in the cell nucleus. The processes of upregulation and downregulation of receptors are explained, along with various types of hormone receptors, including ligand-gated ion channels, G protein–linked hormone receptors, and enzyme-linked hormone receptors. The presentation elaborates on second messenger systems such as adenylyl cyclase, cell membrane phospholipid systems, and calcium-calmodulin linked systems.
Finally, the methods for measuring hormone concentrations in the blood, such as radioimmunoassay and enzyme-linked immunosorbent assays (ELISA), are discussed, providing a comprehensive understanding of the tools used in endocrinology research and clinical practice.
Periodontal disease is a disease, or more likely a number of diseases of the periodontal tissues that results in attachment loss and destruction of alveolar bone. The natural history of periodontal disease, in some but not all patients, results in tooth loss. Periodontal disease, however, encompasses a wider spectrum of diseases than just periodontitis and the recognition of these diseases requires a diagnosis be made.
Classification is the process of identifying and grouping objects or ideas into predetermined categories.
MEDICAL PROFESSIONALISM Class of compassionate care
Ihekuna linda.c seminar presentation
1. A SEMINAR ON
THE ROLE OF GARLIC IN THE MANAGEMENT OF HIGH CHOLESTEROL
PRESENTED BY
IHEKUNA CHIKAODI LINDA
MAT NO: 12/11901
DEPARTMENT OF NUTRITION AND DIETETICS
FACULTY OF HEALTH SCIENCES
IMO STATE UNIVERSITY OWERRI.
IN PARTIAL FULFILLMENT OF REQUIREMENT FOR AWARD OF B.SC.
DEGREE IN NUTRITION AND DIETETICS
SUPERVISOR: Dr EZE-OKEKE C.T
AUGUST, 2016
1
2. INTRODUCTION
Elevated plasma level of cholesterol is linked to the
development of atherosclerosis. This disease results
when LDL-cholesterol deposited in the wall of blood
vessels (Gonona, 1997).
Many studies indicated that lowering plasma
cholesterol may prevent, control and even reverse
atherosclerosis and coronary heart disease (Bierman,
1994).
Lipids have the common property of being
relatively insoluble in water but soluble in non polar
solvent. 2
3. GARLIC (ALLIUM SATIVUM); AN OVERVIEW
Garlic is a perennial plant; belong to the genus allium,
Each clove is separately enclosed in a white scale and
covered with a pinkish-white skin, and the whole
surrounded by layers of white scale leaves ( Mcgee,
2004). .
It is believed to be originated from Central Asia and
extended on the other part of the globe (Etoh et al.,
2001).
The major pharmacological aspects of garlic are
accredited to its characteristic organosulfur compounds
(Tapiero et al., 2004). 3
4. 4
GARLIC BULB AND ITS GLOVES
(www.organicfact.net)
PLATE(1)SHOWING GARLIC BULB
5. CHEMISTRY OF GARLIC
Garlic constituents are categorized into sulfur- and
non-sulfur-containing compounds, The therapeutic
role of garlic is mainly related to the sulfurous
compound like allicin (Schulz, 1998).
ALLICIN
Allicin (dially thiosulfinate), a violent liquid is
responsible for the pungent odor of garlic;
representing approximately 70% of all thiosulfinate
present in the crushed clove (Botlinghaus et al.,
2014).
5
6. ALLICIN CONTD
The component is not found in intact plants, but it is
formed by action of the enzyme named
allinase,derived from a nonproteinogenic amino acid
sallycysteine soxide (aliin) at the time garlic is
crushed (Iciek M et al., 2012).
6
10. CHOLESTEROL LOWERING POTENTIAL OF
GARLIC
Consumption of garlic and garlic preparations
are useful in up regulating the plasma lipid
level (Lau, 2006).
Ologhobo et al., (2008) have elucidated that
garlic imparts inhibitory action on cholesterol
synthesis by halting the activities of
cholesterogenic and lipogenic enzymes owing
to its bioactive constituents like allicin.
10
11. OTHER HEALTH CLAIMS OF
GARLIC
Diabetes is a metabolic syndrome that steadily
affects the physiological system of the human body.
Uncontrolled blood glucose is believed to be the
cardinal feature in the onset of diabetic
complications (Zakir et al., 2008).
According to Nogichi (2007), 33% of all the
diabetic patients take various diet therapies that are
considered effective, among these garlic is one of the
frequently used diet regimen.
11
12. ANTIOXIDANT ACTIVITY
Oxidation of DNA, lipid and protein by reactive
oxygen species plays an important role in the onset
of metabolic syndromes like aging, cardiovascular
complications,etc (Richardson, 1993; Borek, 1997).
Phytonutrients of garlic may act synergistically that
exert antioxidant potential by scavenging ROS
(Borek, 2001), enhancing the cellular antioxidant
enzymes and increasing glutathione in the cells
(Borek, 1997).
12
13. ANTI THROMBOSIS
Thrombus formation plays a key role in the
progression of various maladies like atherosclerosis,
diabetic and cancer insurgence (Boos and Lip, 2006).
Garlic phytonutrients like allicin, diallyltrisulfide
and triallyl sullphide and ajeone act as anti-
thrombosis agents owing to their inhibitory action on
platelet aggregation after interfering arachidonic acid
pathway thus reducing the thrombin formation
(Davison et al., 2012)
13
14. AGING
Aging is a progressive decline in the efficiency of
biochemical and physiological processes within the
physiological system of the body.
The best way to neutralize free radical mediated
oxidative stress in the elderly people is to introduce
diet rich in phytochemicals with antioxidant
properties or to provide dietary supplements
containing antioxidants (Christen, 2000).
14
15. CANCER PERSPECTIVES
Utilization of garlic as an anti-cancer agent was
promoted when Weisberger and Pensky (2010)
reported that its thiosulfinate constituents
repressed the growth of tumor cells.
It is stated that garlic may help to prevent cancer
indirectly by different mechanisms like
inhibition of carcinogen metabolism & increase
detoxification along with excretion from the
body (Guyonnet et al., 1999).
15
16. CONCLUSION
In conclusion, from the reviews of various
literatures, it shows that the role of garlic
in the management of high cholesterol is
significant.
16
17. PROJECT PROPOSAL ON
THE EFFECT OF ALLICIN CONTENT OF GARLIC ON HIGH CHOLESTEROL
USING FEMALE ALBINO RAT
PRESENTED BY
IHEKUNA CHIKAODI LINDA
MAT NO: 12/11901
DEPARTMENT OF NUTRITION AND DIETETICS
FACULTY OF HEALTH SCIENCES
IMO STATE UNIVERSITY OWERRI.
IN PARTIAL FULFILLMENT OF REQUIREMENT FOR AWARD OF B.SC.
DEGREE IN NUTRITION AND DIETETICS
SUPERVISOR: Dr EZE-OKEKE C.T
AUGUST, 2016
17
18. INTRODUCTION
Garlic (Allium sativum L.) is used as a spice and
medicinal herb.
Garlic contains 33 organosulfur compounds (OSC),
several enzymes, 17 amino acids, minerals and
vitamin A, B, C and E (Omar and Al-wabel, 2010).
Several in vitro studies have indicated that garlic
and its component inhibits the key enzyme HMG-
CoA reductase (3hydroxi3 methylglutaryl co
enzyme A) which is associated with cholesterol and
fatty acids synthesis (Yun HM et al., 2014).
18
19. STATEMENT OF PROBLEM
An increased cholesterol level in the blood is
among the leading factors causing
cardiovascular disease in the world.
Unfortunately the use of garlic in the
management of high cholesterol is not well
practiced in our society due to its pungent
odor and dearth of information of its
nutritional competence and importance, hence
the relevance of this study. 19
20. OBJECTIVE OF STUDY
The general objective of the study is to determine the
effect of allicin in high cholesterol diet.
Its specific objectives are to:
Determine the effect of garlic powder on serum LDL
levels of hypercholesterolemia induced rat.
Determine the effect of garlic powder on serum LDL
of normal albino rat.
Determine the effect of garlic powder on serum HDL
and triglycerides level of both normal and
hypercholesterolemia induced albino rat.
Determine the effect of garlic powder on organ 20
21. SIGNIFICANCE OF STUDY
This study will provide information on the
effect of allicin content of garlic on serum
cholesterol.
Effect of its fraction (low density lipoprotein
cholesterol LDL and high density lipoprotein
cholesterol HDL) and triglycerides of
cholesterol feed rat with different levels of
concentration of garlic powder.
21
22. SAMPLE PROCUREMENT
Garlic fresh bulb will be purchased from a local
market in Owerri metropolis.
Albino rat will be obtained from Imo State
University Animal House from Faculty of Medicine
and Health Sciences, the rats will be kept under
standard laboratory condition of 12hours light/dark
cycle and housed in a cage.
SAMPLE PREPARATION
The garlic fresh bulbs will be peeled, cut into pieces
and sundried. The dried bulbs will be grinded into
powder.
22
23. RAT TREATMENT
The rat will be distributed to treatment
using completely randomized design.
Each treatment will contain six rats
and each treatment will have 3
replicates of 2 rats per replicate. A
total of 24 rats will be used for the
study. The study will last for 30 days.
23
24. TREATMENT
1ST TREATMENT – Normal diet +water
2nd TREATMENT – Normal adequate diet+ 1%
addition of cholesterol.
3rd TREATMENT – Normal adequate diet +
250mg/kg body weight addition of garlic.
4th TREATMENT – Normal adequate diet +250
mg/kg body weight addition of garlic +1% addition
of cholesterol
24
25. TABLE 1 SHOWING COMPOSITION OF
RAT RATION
Crude protein = 13%
Fat = 8%
Crude fiber = 15%
Calcium = 0.9%
Phosphorus = 0.35%
Energy = 2600kcal/kg.
25
COMPOSITION OF EXPERIMENTAL DIETS/RATIONS
26. DATA COLLECTION
Rat will be daily monitored. The initial body weight
will be determined and individually weighed every
one week for body weight gain. Their daily food
intake will be recorded during the experimental
period.
At the end of the experiments blood metabolite assay
will be carried out which include the serum lipid
profile of the different section of rats, also the organ
weight of the rats will be assessed.
26
27. STATISTICAL ANALYSIS
All values will be expressed as mean ±SD. The
statistical analysis will be carried out using ANOVAs
i.e analysis of variance and separation of means
using statistical package for social sciences version
20.
EXPECTED RESULT
Expected result will include information on the
positive effect of allicin content of garlic on high
cholesterol using garlic powder on different
treatment of the rat.
27