Natural Treatments for Fibromyalgia, Diabetes, Lupus, Cancer, Multiple Sclero...Douglas Holt
Real Fibromyalgia, Treatment & Emotions
A Pituitary Endocrinology Perspective. Effective natural therapies for Fibromyalgia
Hot flashes, memory loss, and a weird polyneuropathy, polymyalgia or polyarthropathy (i.e. adds up to fibromyalgia)?
What is fibromyalgia? The great magical mystery illness! Pituitary endocrinology research.
Fibromyalgia really is…• Simply pituitary damage. • Causing a lack of several key hormones.
Few pituitary endocrinologists out there. Out of 150 endocrinologists there will be 1 true Pituitary Endocrinologist.
Fibromyalgic syndromes: could growth hormone therapy be beneficial?
Diabetes, Lupus, Cancer, multiple sclerosis, gout, rheumatoid arthritis, arthritis, lymphoma, glucose, osteoarthritis, type 2 diabetes, fatigue, chronic fatigue syndrome, dizziness, autoimmune disease, adrenal fatigue, polymyalgia rheumatica, depression, why am I so tires
Actual Causes of Fibromyalgia?
The pituitary secretes hormones that are essential to growth and reproduction. Hormones and vasculature.
Problems that can cause stalk or pituitary damage:
• Whiplash or any MVA
• TBI – even mild (Australian Rules Football would qualify)
• Air Bag Deployment to face or head
• Any Mild to Moderate Blows To The Head – heading a soccer ball! Any concussion!
• Sexual abuse as a child
• Stroke
• Tumors – if you can’t find anything else!
• Sheehan’s Syndrome
• Snorting or huffing drugs (i.e. cocaine)
• Radiation exposure (i.e. MD/DO/DC/DDS)
• Prolonged High Stress (i.e. MD/DO/DC/DDS)
Pituitary Dysfunction = Fibromyalgia = Maybe Even Multiple Sclerosis (MS)
Fibromyalgia Really Occurs from a Lack of Healing Hormones
Occurrence of pituitary dysfunction following traumatic brain injury. “subjects with a history of TBI frequently develop pituitary dysfunction, especially GHD.” (GHD=Growth Hormone Deficiency)
Lack of Testosterone is a problem, too.
Sage (Salvia officinalis), fennel (Foeniculum vulgare), lavender (Lavandula angustifolia), myrtle (Myrtus communis), peppermint (Mentha piperita), and blue yarrow (Achillea millefolium), in a base of sesame seed oil.
Symptoms of Inadequate Progesterone Production?
• Hot Flashes
• Day and Night Sweats
• Migraine Headaches
• Severe PMS
• Endometriosis
• Demyelination Problems
• TMJ Problems (not usually the only cause)
• Libido Problems
For diagnoses related to hypothyroidism, typical problems include fatigue, weight gain, depression, lethargy, dry skin, cold intolerance, voice change, change in menses, muscle cramps, or treatment of a thyroid condition.
Here’s the emotional tie in
• Depression, lethargy, fatigue.
• Lack of HGH causes PTSD, depression, fatigue, confusion.
• Low testosterone causes decreased libido, fatigue, depression.
• Lack of progesterone causes depression, fatigue, PMS.
“Progesterone prevents menstrual migraine headaches in women.”
Lack of Thyroid Causes Hair Loss
I was asked to present something on Fibromyalgia during a Pain Summit. I ended up describing what we know so far about clinical features, evolution of diagnostic criteria and synthesized some recent guidelines.
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain and tenderness. It is more common in women than men. While pain is the primary symptom, it also involves fatigue, sleep issues, cognitive problems, anxiety and depression. There is no known cause but factors like genetics and abnormal pain processing in the central nervous system may play a role. Treatment involves lifestyle changes like exercise and stress management as well as medications like antidepressants. While not curable, some patients are able to adapt well through treatment, but a minority have severe, treatment-resistant symptoms.
- Fibromyalgia affects 3 to 6 million Americans, with 80-90% being women who are usually diagnosed in middle age.
- It is characterized by widespread pain in the muscles and soft tissues. Common symptoms include fatigue, sleep issues, headaches, and tender points in various areas of the body.
- While drugs can help manage symptoms, natural therapies like exercise, stress reduction, and nutrition have shown more long-term promise for fibromyalgia sufferers. Regular exercise in particular can help reduce pain and fatigue and improve overall health.
Fibromyalgia is a rheumatic disorder characterized by chronic widespread muscle pain. It primarily affects women ages 30 to 50 and is diagnosed when a patient has 11 of 18 tender points. Conventional treatments like antidepressants may provide short-term relief but have side effects. Holistic treatments aim to address underlying causes like food allergies, infections, poor nutrition and sleep. Lifestyle changes like exercise, stress reduction and dietary modifications can help manage symptoms.
Fibromyalgia syndrome is a common and chronic disorder characterized
by widespread pain, diffuse tenderness, and a number of other symptoms.
The word “fibromyalgia” comes from the Latin term for fibrous tissue (fibro) and the Greek ones for muscle (myo) and pain (algia).
Although fibromyalgia is often considered an arthritis-related
condition, it is not truly a form of arthritis (a disease of the joints)
because it does not cause inflammation or damage to the joints,
muscles, or other tissues. Like arthritis, however, fibromyalgia can
cause significant pain and fatigue, and it can interfere with a person’s
ability to carry on daily activities. Also like arthritis, fibromyalgia
is considered a rheumatic condition, a medical condition that impairs
the joints and/or soft tissues and causes chronic pain.
In addition to pain and fatigue, people who have fibromyalgia may experience a variety of other symptoms including:
-- cognitive and memory problems (sometimes referred to as “fibro fog”)
-- sleep disturbances
-- morning stiffness
-- headaches
-- irritable bowel syndrome
-- painful menstrual periods
-- numbness or tingling of the extremities
-- restless legs syndrome
-- temperature sensitivity
-- sensitivity to loud noises or bright lights.
Fibromyalgia is a syndrome rather than a disease. A syndrome is a
collection of signs, symptoms, and medical problems that tend to occur
together but are not related to a specific, identifiable cause. A
disease, on the other hand, has a specific cause or causes and
recognizable signs and symptoms.
A person may have two or more coexisting chronic pain conditions.
Such conditions can include chronic fatigue syndrome, endometriosis,
fibromyalgia, inflammatory bowel disease, interstitial cystitis,
temporomandibular joint dysfunction, and vulvodynia. It is not known
whether these disorders share a common cause.
Have you ever had one of those extreme headaches that ruthlessly affect your quality of work? If you are suffering from chronic widespread pain and sharp painful response to pressure, known as allodynia in medical terms, then you might be experiencing Fibromyalgia.
Fibromyalgia is a disorder characterized by widespread musculoskeletal pain, stiffness, and tender points. It predominantly affects women and prevalence increases with age. The diagnosis is based on a history of widespread pain for at least 3 months and pain in 11 of 18 tender points. While the cause is unknown, it involves central sensitization and neuroendocrine abnormalities. Treatment includes medications, exercise, stress management, CBT, and alternative therapies. The ACR is proposing new diagnostic criteria incorporating symptoms like fatigue and cognitive problems in place of tender points.
Fibromyalgia is a disease, which is difficult to diagnose. These slides include ACR criteria 1990 and 2010 with Wide spread pain index(WPI) and Symptom severity score(SSS)
Fibromyalgia is a condition characterized by widespread pain throughout the body and affects 2-4% of the population, predominantly women. Common symptoms include fatigue, joint stiffness, muscle pain, and mood issues like depression and anxiety. While the cause is unknown, risk factors include heredity, injuries, infections, and psychological stress. Treatment options consist of medications like Lyrica, Cymbalta, and antidepressants as well as exercise, which can help reduce pain and fatigue while improving mood, though overexertion risks exacerbating symptoms.
Fibromyalgia is a syndrome characterized by chronic widespread pain, stiffness, and tenderness in the muscles and joints without signs of inflammation. It predominantly affects women between 35-55 years old and causes significant pain and fatigue that interferes with daily activities. While the exact cause is unknown, fibromyalgia is diagnosed by identifying tender points on the body and treatment focuses on managing symptoms through exercise, stress reduction, medications, and alternative therapies as there is no cure.
Fibromyalgia: Fact or Fiction? A Multi-disciplinary ApproachMedicineAndHealthUSA
Fibromyalgia is a chronic pain condition defined by widespread muscle pain and tender points. It has overlapping symptoms with conditions like chronic fatigue syndrome, irritable bowel syndrome, and depression or anxiety. Treatment requires a multidisciplinary approach including medications, exercise, stress management, and sleep improvement to help manage pain and associated symptoms.
Aching Muscles? Tired? Rejuvenate with Homeopathy! Treat that Niggling Fibrom...Welcome Cure LLP
Fibromyalgia causes pains and tenderness in many areas of the body, and tiredness. Working adults with it have reported almost 17 days of missed work per year as compared to 6 days for people without Fibromyalgia. Body parts are very sensitive to touch and painful on pressure. It is seven times more common in women than in men. Homeopathy provides long-lasting relief of the aches and pains and other symptoms associated with Fibromyalgia. You can find more of such informative Power Point Presentations as well as other useful health information at www.welcomecure.com, the definitive online homeopathic treatment portal.
www.welcomecure.com
Fibromyalgia is a disorder characterized by widespread pain, abnormal pain processing, sleep disturbances, fatigue, and often psychological distress. The cause is unknown, but may involve genetic and environmental factors. Central nervous system changes, including increased brain activity and premature gray matter loss, are believed to play a role in fibromyalgia by enhancing pain sensitivity. Diagnosis involves a history of chronic widespread pain for over 3 months, along with sleep issues and tender points found in 11 of 18 body areas upon examination.
This document provides an overview of fibromyalgia, including:
- Fibromyalgia causes widespread pain, fatigue, and other types of discomfort throughout the body. While symptoms resemble arthritis, it affects soft tissues rather than joints.
- Common symptoms include widespread pain, headaches, fatigue, sleep issues, and fibro-fog. The cause is unknown but may involve genetics and traumatic injuries.
- Treatment options aim to relieve symptoms and improve sleep, including exercise, acupuncture, psychotherapy, and some medications. People need to work with their doctor to develop an individualized treatment plan.
Fibromyalgia is a clinical syndrome characterized by widespread pain, fatigue, sleep disturbances, and other somatic and cognitive symptoms. It affects 2-5% of the general population and is more prevalent among women ages 20-50. The cause is unclear but may involve genetic and environmental factors as well as abnormalities in central pain processing and neuroendocrine function. Diagnosis is based on symptoms and involves assessing pain levels and tender points. Treatment focuses on managing symptoms and includes pharmacologic approaches like antidepressants as well as non-pharmacologic options such as exercise, therapy, and acupuncture. Acupuncture is thought to help fibromyalgia by inhibiting pain pathways, stimulating pain modulation pathways, and regulating neuroendocrine function like cortisol and growth hormone levels
12.04.08(a): Pathogenesis and Treatment of FibromyalgiaOpen.Michigan
Slideshow is from the University of Michigan Medical School's M2 Musculoskeletal sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M2Muscu
This document provides an overview of fibromyalgia including what it is, possible causes, symptoms, and treatment approaches. It discusses fibromyalgia as a condition with widespread pain and tender points, and notes that the cause is unknown but may involve genetic and environmental factors like physical or emotional trauma. Common symptoms are described as pain, sleep disturbances, fatigue, and mood issues. The document outlines a framework for understanding fibromyalgia as a dysregulation of the stress response and hypothalamic-pituitary-adrenal axis. Practical management tips focus on diet, natural remedies, pain management, and improving sleep. A follow up session is scheduled to provide more detail on topics like mood issues, gastrointestinal problems, and advances in understanding fibromyalgia.
Fibromyalgia is a chronic disorder characterized by widespread muscle pain, tenderness, and stiffness. It predominantly affects women between 25-55 years old. Common symptoms include fatigue, headaches, sleep disturbances, and abnormal pain sensation. While the cause is unknown, genes and physical trauma may play a role. Treatments include exercise, acupuncture, massage, medications, and psychotherapy to manage pain and fatigue.
This ebook is packed with detailed information about the most effective means of treating Fibromyalgia. Experts and Researchers agree that a "Patient Directed" Fibromyalgia management program is the best treatment approach. While dozens of proven effective treatment options are discussed at length, the focus of this book is on the process of putting systems to use in researching, planning, implementing and managing the development of an individualized Fibromyalgia treatment program. Through the key concept of "Intelligent" Trial and Error - this ebook will teach you a more effective means of managing your Fibromyalgia on a daily basis.
Myasthenia gravis is an either autoimmune or congenital neuromuscular disease that leads to fluctuating muscle weakness and fatigue. In the most common cases, muscle weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the excitatory effects of the neurotransmitter acetylcholine on nicotinic receptors at neuromuscular junctions. Alternatively, in a much rarer form, muscle weakness is caused by a genetic defect in some portion of the neuromuscular junction, that is inherited at birth as opposed to developing it through autoimmunity later in life or through passive transmission by the mother's immune system at birth.
Myasthenia gravis is an autoimmune neuromuscular disorder characterized by weakness and fatigability of skeletal muscles. It results from antibodies that block or destroy acetylcholine receptors at the neuromuscular junction, reducing signal transmission from nerves to muscles. Common symptoms include ptosis, diplopia, and weakness of proximal limb muscles or bulbar muscles. Diagnosis involves history, physical exam, electrodiagnostic testing showing decremental response to repetitive nerve stimulation, and presence of acetylcholine receptor antibodies. Treatment options include anticholinesterase medications, immunosuppression, plasmapheresis, IVIg, and thymectomy.
Myasthenia gravis is an autoimmune disorder characterized by varying degrees of weakness in voluntary muscles. It occurs when antibodies block or damage receptors at the neuromuscular junction, preventing normal muscle contraction in response to nerve impulses. Risk factors include female gender under 40, male gender over 60, and other autoimmune disorders. Symptoms include drooping eyelids, blurred or double vision, weakness in the face, and generalized weakness that worsens with activity. Diagnostic tests include the edrophonium test, blood tests for antibodies, repetitive nerve stimulation, and pulmonary function tests. Treatment involves cholinesterase inhibitors, corticosteroids, immunosuppressants, and in some cases plasmapher
This document discusses pain in children and adolescents, including musculoskeletal pain, fibromyalgia, and central pain processing disorders. It notes that 25% of new patients seen by pediatric rheumatologists have childhood pain syndromes, with average age of onset being 12 years old. Musculoskeletal pain affects 6% of pediatric primary care visits. The document defines different types of pain including nociceptive, neuropathic, and central pain processing. It discusses how conditions like fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome may involve central pain processing and sensitization. Treatment options discussed include validation, education, exercise, cognitive behavioral therapy, and various pharmacologic approaches.
1) Fibromyalgia is a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and other symptoms. It is considered a central sensitization syndrome where the central nervous system amplifies sensory processing and pain perception.
2) Treatment involves both pharmacological and non-pharmacological strategies including exercise, stress management, cognitive behavioral therapy, and acupuncture. Acupuncture aims to regulate the central neurotransmitters involved in pain processing and sensory amplification associated with fibromyalgia.
3) Management of fibromyalgia requires a multimodal approach targeting symptoms like pain and fatigue, as well as underlying mechanisms of central sensitization. The goal is to improve patient function through a combination of lifestyle management and integrated medical therapies.
Fibromyalgia is a chronic condition characterized by widespread muscle pain, fatigue, and tender points. It is more common in women. While the cause is unknown, it is thought to involve increased sensitivity in the brain to pain signals. Symptoms vary but include muscle pain, fatigue, sleep issues, headaches, and numbness. There is no lab test to diagnose it, but diagnosis involves a history of widespread pain for over 3 months and tender points in specific areas. Treatments focus on reducing pain and improving sleep and function through medications and lifestyle changes.
The document discusses various topics related to pain, including definitions, types, causes, symptoms, investigations, and treatments. It defines pain and differentiates it from nociception. It describes acute and chronic pain, as well as types including malignant and non-malignant pain. Physiological pain origins like cutaneous, somatic, and visceral pain are explained. Common and serious causes of pain in different body regions are listed. Investigations and various allopathic and alternative pain treatment methods are also outlined.
This document provides an overview of fibromyalgia, including its classification, symptoms, causes, diagnosis, treatment, and the role of physical therapists. Fibromyalgia is classified as a central nervous system disorder characterized by widespread muscle pain and tender points. It commonly causes fatigue, sleep issues, and mood changes. While its causes are unclear, factors like genetics, trauma, and sleep disturbances may play a role. Physical therapists can help patients with fibromyalgia develop exercise and stretching routines to reduce pain and stiffness.
The document provides information about fibromyalgia, including its traditional and newer definitions, common symptoms, diagnosis criteria, differential diagnosis with other conditions like ME/CFS, the pain cycle model, precipitating and perpetuating factors, treatment approaches, and recent research findings. It discusses a multidisciplinary approach to treatment involving mechanical, biochemical, emotional, dietary, exercise, and medication-based interventions.
lower, upper and middlepain-management-2010.pptAfframHspt
This document provides an overview of pain management in the geriatric population. It discusses that pain is undertreated in elderly patients due to barriers like comorbidities, polypharmacy, and practitioner bias. The document differentiates between nociceptive, neuropathic, somatic, and visceral pain and how this impacts treatment. Both pharmacological and non-pharmacological approaches to pain management are covered. Common pain conditions in elderly patients and age-related changes that impact pain perception are also reviewed.
This document discusses pain assessment and management in the emergency department. It defines different types of pain and provides terminology related to pain. The pathophysiology of pain is explained, including nociceptors, pain fiber transmission, and the body's natural pain modulation system using endogenous opioids. Barriers to effective pain management are outlined. Methods for assessing and treating pain are presented, including pharmacologic options like opioids and NSAIDs as well as non-pharmacologic approaches. Procedural sedation is also briefly discussed.
Pain is an unpleasant sensory and emotional experience caused by actual or potential tissue damage. It serves a protective function by warning us of damage. Pain is transmitted through specialized pain pathways and is classified based on duration, location, and source. There are different types of pain receptors that detect various painful stimuli and transmit signals through different nerve fiber types to the central nervous system where pain is perceived.
The document discusses chronic pain and its differences from acute pain. It notes that chronic pain has different pathophysiology, including sensitization and changes in pain threshold. Treatment for chronic pain also differs and involves addressing more than just nociception. The document presents several case studies to illustrate features of chronic pain, including impacts on mood, behavior, function and the multifaceted nature of chronic pain. It also outlines the scope and definition of chronic pain medicine.
Fibromyalgia is a chronic pain condition characterized by widespread muscle aches, pain and fatigue. While the exact cause is unknown, it involves dysregulation of the autonomic nervous system and neuroendocrine changes. The American College of Rheumatology diagnostic criteria includes widespread pain for over 3 months and tender points found in 11 of 18 sites. Treatment options with mild to moderate effectiveness include low-dose antidepressants, aerobic exercise and cognitive behavioral therapy, though more research is still needed on alternative therapies.
This document discusses pain physiology, treatment options for pain, and common questions about pain. It explains that pain receptors detect potentially harmful stimuli and transmit pain messages to the spinal cord and brain. The brain then processes the pain and can send signals to reduce pain perception. Treatment options discussed include medications, mind-body practices, and self-care activities. Common questions addressed relate to aging and pain, assessing pain levels, medication risks and benefits, and the role of psychological factors in chronic pain.
Fibromyalgia is a disorder characterized by long-term, body-wide pain and tenderness in the joints, muscles, tendons and soft tissues. The cause is unknown, but may involve physical or emotional trauma, abnormal pain response, sleep disturbances or infection. Symptoms include pain at specific tender points throughout the body, fatigue, depressed mood and sleep problems. To be diagnosed, a person must have widespread pain and tenderness in at least 11 of 18 areas of the body for over 3 months. While there is no cure, treatment aims to relieve pain through physical therapy, exercise, medications or stress relief methods.
A disease characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints, without detectable inflammation.
this study gives a brief idea about the facts , causes , diagnosis and some other factors of fibromyalgia .
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Transverse myelitis is an inflammation of the spinal cord that damages the protective myelin sheath surrounding nerve fibers. It causes symptoms like pain, muscle weakness, paralysis, and problems with bladder and bowel function. The exact cause is unknown but may result from infections, immune disorders, or other medical conditions. Diagnosis involves exams and tests like MRI or spinal tap. Treatment focuses on reducing inflammation with steroids or plasma exchange and managing symptoms with pain medication, physical therapy, and nursing care like skin care and bladder management. Complications can include permanent paralysis, pain, spasms, and depression.
This document outlines the components and purpose of a scanning examination performed in physical therapy. The scanning exam is used to ensure issues are within the scope of physical therapy and rule out serious pathology. It involves observation of gait and posture, vital signs, functional movement testing, tissue tension testing, palpation, neurological exams, and special tests. The purpose is to detect gross loss of function and movement control in order to guide further physical therapy diagnosis and treatment.
A lecture about Technology in Physical Therapy Practice. Given at the OPTA Western District Meeting on 06/30/11 by Casey Kirkes PT, DPT and Dale Boren Jr. PT, MPT, O
This new employee orientation covers the following key points in 3 sentences:
The orientation reviews PTC's core values, the employee's role and responsibilities, professional development training, who the various company partners are, documentation and billing standards, and emphasizes having fun while embracing change. Employees will complete personality and learning assessments, learn about mentoring resources, and get an overview of performance reviews, social media guidelines, and the importance of teamwork and excellent customer service. The goal is to onboard new employees effectively and get them started on a path of continued learning and professional growth as part of the PTC team.
This document summarizes research on the treatment of femoroacetabular impingement (FAI) with manual therapy. It discusses the anatomy and causes of FAI, as well as diagnosis using imaging and clinical exams. While evidence directly comparing manual therapy to exercise for FAI is limited, manual therapy techniques used successfully for hip osteoarthritis may also benefit FAI by increasing range of motion and reducing pain. Case reports show positive outcomes with manual therapy including traction, mobilization, and soft tissue techniques for FAI patients. More research is still needed on rehabilitation approaches for FAI.
The document provides information on medical red flags and common red flags associated with various body regions. It defines red flags as signs or symptoms that may warrant referral to another provider. The document then summarizes several studies on red flag documentation and lists many common red flags for various areas including back, chest/ribs, shoulder, sacrum/pelvis, lower quadrant, and leg. Red flags listed indicate potential serious conditions needing referral such as cancer, infection, fractures, or cardiovascular issues.
The document provides information on performing a differential diagnosis examination for the hip. It discusses evaluating the hip for common conditions like osteoarthritis, fractures, bursitis, labral tears, and referred pain from the low back. Physical examination tests are outlined to help determine the likely cause of hip pain, including assessing range of motion, special tests, and risk factors. The goal is to systematically examine the hip to form an evidence-based diagnosis and guide appropriate treatment.
This document provides an overview of a physical therapy course on total hip rehabilitation. The course objectives are to understand hip surgery and exercises, describe hip biomechanics, and effectively progress patients through rehabilitation. The schedule covers topics like evidence-based practice, anatomy, exercises, and outcome measures. Recent advances in hip rehabilitation include smaller incisions, reduced hospital stays, and early mobilization leading to better short-term outcomes. Assessment tools for hip function include the Lower Extremity Function Scale and Harris Hip Score.
This document provides a reading list and brief summaries of books recommended by Physical Therapy Central, Inc. It recommends several business and self-help books, including Michael Levine's "Broken Windows", which is described as a short, easy read; Tom Rath's "StrengthFinder 2.0", which helped change the author's thinking; and Jim Collins' "Good to Great", which helped focus the author and change how they run their business. It also lists books by Eckhart Tolle, Malcolm Gladwell, Michael Gerber, and others and provides short blurbs about each.
This document provides a reading list and brief summaries of books recommended by Physical Therapy Central, Inc. It recommends several business and self-help books, including Michael Levine's "Broken Windows", which is described as a short, easy read; Tom Rath's "StrengthFinder 2.0", which helped change the author's thinking; and Jim Collins' "Good to Great", which helped focus the author and change how they run their business. It also lists books by Eckhart Tolle, Malcolm Gladwell, Michael Gerber, and others and provides short blurbs about each.
Chair, Benjamin M. Greenberg, MD, MHS, discusses neuromyelitis optica spectrum disorder in this CME activity titled “Mastering Diagnosis and Navigating the Sea of Targeted Treatments in NMOSD: Practical Guidance on Optimizing Patient Care.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/4av12w4. CME credit will be available until June 27, 2025.
Hepatocarcinoma today between guidelines and medical therapy. The role of sur...Gian Luca Grazi
Today more than ever, hepatocellular carcinoma therapy is experiencing profound and substantial changes.
The association atezolizumab (ATEZO) plus bevacizumab (BEVA) has demonstrated its effectiveness in the post-operative treatment of patients, improving the results that can be achieved with liver resections. This after the failure of the use of sorafenib in the already historic STORM study.
On the other hand, the prognostic classification of BCLC is now widely questioned. It is now well recognized that the indications for surgery for patients with hepatocellular carcinoma are certainly narrow in BCLC and no longer reflect what is common everyday clinical practice.
Today, the concept of multiparametric therapeutic hierarchy, which makes the management of patients with hepatocellular carcinoma much more flexible and allows the best therapy for the individual patient to be identified based on their clinical characteristics, is gaining more and more importance.
The presentation traces these profound changes that are taking place in recent years and offers a modern vision of the management of patients with hepatocellular carcinoma.
JMML is a rare cancer of blood that affects young children. There is a sustained abnormal and excessive production of myeloid progenitors and monocytes.
A comparative study on uroculturome antimicrobial susceptibility in apparentl...Bhoj Raj Singh
The uroculturome indicates the profile of culturable microbes inhabiting the urinary tract, and it is often required to do a urine culture to find an effective antimicrobial to treat UTIs. This study targeted to understand the profile of culturable pathogens in the urine of apparently healthy (128) and humans with clinical UTIs (161). In urine samples from UTI cases, microbial counts were 1.2×104 ± 6.02×103 colony-forming units (cfu)/ mL, while in urine samples from apparently healthy humans, the average count was 3.33± 1.34×103 cfu/ mL. In eight samples (six from UTI cases and two from apparently healthy people) of urine, Candida (C. albicans 3, C. catenulata 1, C. krusei 1, C. tropicalis 1, C. parapsiplosis 1, C. gulliermondii 1) and Rhizopus species (1) were detected. Candida krusei was detected only in a single urine sample from a healthy person and C. albicans was detected both in urine of healthy and clinical UTI cases. Fungal strains were always detected with one or more types of bacteria. Gram-positive bacteria were more commonly (OR, 1.98; CI99, 1.01-3.87) detected in urine samples of apparently healthy humans, and Gram -ve bacteria (OR, 2.74; CI99, 1.44-5.23) in urines of UTI cases. From urine samples of 161 UTI cases, a total of 90 different types of microbes were detected and, 73 samples had only a single type of bacteria. In contrast, 49, 29, 3, 4, 1, and 2 samples had 2, 3, 4, 5, 6 and 7 types of bacteria, respectively. The most common bacteria detected in urine of UTI cases was Escherichia coli detected in 52 samples, in 20 cases as the single type of bacteria, other 34 types of bacteria were detected in pure form in 53 cases. From 128 urine samples of apparently healthy people, 88 types of microbes were detected either singly or in association with others, from 64 urine samples only a single type of bacteria was detected while 34, 13, 3, 11, 2 and 1 samples yielded 2, 3, 4, 5, 6 and seven types of microbes, respectively. In the urine of apparently healthy humans too, E. coli was the most common bacteria, detected in pure culture from 10 samples followed by Staphylococcus haemolyticus (9), S. intermedius (5), and S. aureus (5), and similar types of bacteria also dominated in cases of mixed occurrence, E. coli was detected in 26, S. aureus in 22 and S. haemolyticus in 19 urine samples, respectively. Gram +ve bacteria isolated from urine samples' irrespective of health status were more often (p, <0.01) resistant than Gram -ve bacteria to ajowan oil, holy basil oil, cinnamaldehyde, and cinnamon oil, but more susceptible to sandalwood oil (p, <0.01). However, for antibiotics, Gram +ve were more often susceptible than Gram -ve bacteria to cephalosporins, doxycycline, and nitrofurantoin. The study concludes that to understand the role of good and bad bacteria in the urinary tract microbiome more targeted studies are needed to discern the isolates at the pathotype level.
Hemodialysis: Chapter 8, Complications During Hemodialysis, Part 2 - Dr.GawadNephroTube - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/FHV_jNJUt3Y
- Video recording of this lecture in Arabic language: https://youtu.be/D5kYfTMFA8E
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
EXPERIMENTAL STUDY DESIGN- RANDOMIZED CONTROLLED TRIALRishank Shahi
Randomized controlled clinical trial is a prospective experimental study.
It essentially involves comparing the outcomes in two groups of patients treated with a test treatment and a control treatment, both groups are followed over the same period of time. Prepare a plan of study or protocol
a. Define clear objectives
b. State the inclusion and exclusion criteria of case
c. Determine the sample size, place and period of study
d. Design of trial (single blind, double blind and triple blind method)
2. Define study population: Most often the patients are chosen from hospital or from the community. For example, for a study for comparison of home and sanatorium treatment, open cases of tuberculosis may be chosen.
3. Selection of participants by defined criteria as per plan:
Selection of participants should be done with precision and should be precisely stated in writing so that it can be replicated by others. For example, out of open cases of tuberculosis those who fulfill criteria for inclusion may be selected (age groups, severity of disease and treatment taken or not, etc.)
Randomization ensures that participants have an equal chance to be assigned to one of two or more groups:
One group gets the most widely accepted treatment (standard treatment/ gold standard)
The other gets the new treatment being tested, which researchers hope and have reason to believe will be better than the standard treatment
Subject variation: First, there may be bias on the part of the participants, who may subjectively feel better or report improvement if they knew they were receiving a new form of treatment.
Observer bias: The investigator measuring the outcome of a therapeutic trial may be influenced if he knows beforehand the particular procedure or therapy to which the patient has been subjected.
Evaluation bias: There may be bias in evaluation - that is, the investigator(Analyzer) may subconsciously give a favorable report of the outcome of the trial.
Co-intervention:
participants use other therapy or change behavior
Study staff, medical providers, family or friends treat participants differently.
Biased outcome ascertainment:
participants may report symptoms or outcomes differently or physicians
Investigators may elicit symptoms or outcomes differently
A technique used to prevent selection bias by concealing the allocation sequence from those assigning participants to intervention groups, until the moment of assignment.
Allocation concealment prevents researchers from influencing which participants are assigned to a given intervention group.
All clinical trials must be approved by Institutional Ethics Committee before initiation
It is mandatory to register clinical trials with Clinical Trials Registry of India
Informed consent from all study participants is mandatory.
A preclinical trial is a stage of research that begins before clinical trials, and during which important feasibility and drug safety data are collected.
Following points high.
Exploring Alternatives- Why Laparoscopy Isn't Always Best for Hydrosalpinx.pptxFFragrant
Not all women with hydrosalpinx should choose laparoscopy. Natural medicine Fuyan Pill can also be a nice option for patients, especially when they have fertility needs.
Chemical kinetics is the study of the rates at which chemical reactions occur and the factors that influence these rates.
Importance in Pharmaceuticals: Understanding chemical kinetics is essential for predicting the shelf life of drugs, optimizing storage conditions, and ensuring consistent drug performance.
Rate of Reaction: The speed at which reactants are converted to products.
Factors Influencing Reaction Rates:
Concentration of Reactants: Higher concentrations generally increase the rate of reaction.
Temperature: Increasing temperature typically increases reaction rates.
Catalysts: Substances that increase the reaction rate without being consumed in the process.
Physical State of Reactants: The surface area and physical state (solid, liquid, gas) of reactants can affect the reaction rate.
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POTENTIAL TARGET DISEASES FOR GENE THERAPY SOURAV.pptxsouravpaul769171
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3. Introduction Fibromyalgia – what is it? Be skeptical if you read something that says it will “cure” symptoms. Patients need to understand their symptoms so that they can begin to take control and manage their pain.
4. Overview Common condition characterized by long-term, body-wide pain and tender points in joints, muscles, tendons, and other soft tissue. A chronic pain state. Nerve stimuli causing pain (reduced pain threshold). Symptoms: fatigue, morning stiffness, sleep problems, headaches, depression and anxiety.
5. Fibromyalgia A common and complex chronic pain disorder that affects people physically, mentally and socially. It is a syndrome rather than a disease. A disease, which is a medical condition with specific cause or causes and recognizable signs and symptoms. Fibromyalgia is a set of symptoms not caused by a disease. A syndrome is a collection of signs and symptoms that occur together without an identifiable cause.
6. Science of Fibromyalgia Tends to be treated rather dismissively by Medical Community. Controversy – not disease process, can’t be cured. Problem with doctors is that it can not be understood according to the classic medical model. This model is used with all medical training. Tissue pathology with distinctive symptoms and a causative agent. Tuberculosis, causing a chronic cough, tubercule bacillus is causative agent and can be cured.
7. What is the problem? It is not a primary psychological disorder. As in many chronic conditions, psychological factors may play a role. May “up regulate” the central nervous system. Abnormal pain transmission response Disordered sensory processing.
8. What is the problem? The stimuli causing pain originates mainly in the muscles. Skeletal muscle metabolism – decrease blood flow Hence the increased pain with strenuous exertion.
9. Perception of Pain Pain is a universal experience that serves the vital function of triggering avoidance. Cardinal symptom of FM is widespread body pain. Tender points at musculoskeletal junction. Amplification of nervous system. Some 30 years ago, Melzeck and Wall proposed that pain is a complex integration of noxious stimuli, and cognitive factors. In other words, the emotional aspects of having a chronic pain state and one's rationalization of the problem may both influence the final experience of pain.
10. Description a chronic musculoskeletal syndrome characterized by widespread: musculoskeletal aches and pain stiffness in the muscle tissue, ligaments, and tendons soft tissue tenderness general fatigue sleep disorders gastrointestinal disorders depression affects the neck, shoulders, chest, legs, and lower back symptoms similar to those of chronic fatigue syndrome and myofascial pain syndrome.
11. Significance 10 million US 3-6% of population ~ 80% are women highest incidence women 20 to 40 years of age Genetic component Among siblings and mothers and daughters Incidence rises with age, by 80 years old – 8% of the population.
12. Risk Factors Age more common in young adults, increases with age Gender more common in women Genetic familial patterns suggest the disorder may be inherited Often follows a trauma infectious or stress Sleep disorders unknown whether sleep difficulties are a cause or a result of fibromyalgia Rheumatic Disease RA or Lupus more likely to develop FA
13. Pathophysiology unknown etiology produces vague symptoms that may be associated with diminished blood flow to certain parts of the brain and increased amounts of substance P substance P thought to be a sensory neurotransmitter involved in the communication of pain, touch, and temperature from body to brain. Lowers the threshold of synaptic excitability
14. Pathophysiology several other possible causes: autonomic nervous system dysfunction chronic sleep disorders emotional stress or trauma immune or endocrine system dysfunction upper spinal cord injury viral or bacterial infection
15. Signs and Symptoms vary, depending on stress level, physical activity, time of day, and the weather pain primary symptom pain and tenderness in specific trigger points when pressure is applied aching, burning, throbbing, or move around the body (migratory) muscle tightness, soreness, and spasms unable to carry out normal daily activities even though muscle strength is not affected pain often worse in morning, improves throughout day, worsens at night
16. Signs and Symptoms symptoms may be constant or intermittent for years common symptoms include: sleep disorders restless leg syndrome, sleep apnea gastrointestinal abdominal pain, bloating, gas, cramps, alternating diarrhea and constipation, IBS numbness or tingling sensations chronic headaches may include facial and jaw pain heightened sensitivity to odors, loud noises, bright lights, various foods, medicines, changes in weather frequent urination, strong urge to urinate, painful urination (dysuria) sensation of swelling (edema) in hands and feet even though not present cognitive or memory impairment post-exertional malaise and muscle pain morning stiffness (waking up stiff and achy)
17. Trigger Points Main points of pain in Fibromyalgia patients Neck Back Shoulders Pelvic Girdle Hands Knees Elbows Hips
18. Diagnosis No laboratory tests Must rely on patients self reported symptoms 3 month history Exam based on American College of Rheumatology criteria. Estimated that it takes an average of five years to get diagnosed. Exclusion of other conditions chronic fatigue syndrome and myofascial pain syndrome
19. To receive a diagnosis of FM Medical History widespread pain in all four quadrants of their body for a minimum of three months at least 11 of the 18 specified tender points when pressure is applied.
20. Rule Out other Conditions Cancer Cervical & Lumbar DDD Chronic Fatigue Depression Hypothyroidism Irritable Bowel Syndrome Rheumatoid Arthritis Sleep Disorders
21. Myth Fibromyalgia Damages Your Joints Increase pain has not been correlated with any joint or muscle damage. It is important to understand that activity is good for your joints and will help patients with Fibromyalgia control pain. Fibromyalgia is not fatal True
22. Myth You look fine, so nothing is wrong with you. Pain is cultural Our society does not really want to know “How are you?” You were diagnosed with fibromyalgia because your doctor couldn’t find anything wrong with you. American College of Rheumatology
23. Treatment Pain Management Lifestyle adjustment avoid nonessential activities Good Nutrition Stress Management Use of relaxation techniques meditation, biofeedback Exercise Sleep Management Avoid caffeine Regular sleep routine
25. Pain Management Goal reduce pain, improve sleep, and relieve associated symptoms Medication antidepressant agents relieve sleep disorders, reduce muscle pain, treat depression small doses of aspirin or acetaminophen relief of pain and muscle stiffness Lyrica/cymbalta/Savella - Trigger point injections injection of local anestheticand/or corticosteroid into a tender point and then stretching involved muscle local anesthetic blood flow to the muscle corticosteroids inflammation
26. Treatment Exercise low-impact aerobic activity and strength training. 25-60% HHR, 3days/week, 20-30 minutes Significant decrease in the Fibromyalgia Impact Questionnaire ACSM Guidelines are too strenuous Physical Therapy Modalities Manual therapy Stretching C-V
27. Prognosis No cure – lifelong condition. Very rare for them to develop lupus or MS Better ways to diagnose and treat the chronic pain disorder continue to be developed. FDA – new medications Clinical studies demonstrate that can reduce symptoms. Does not shorten life span.
28. Support Groups National Fibromyalgia Association www.fmaware.org Podcasts Walk of FAME (Fibromyalgia Awareness Means Everything) Emotional/Social Support and Education