Angular cheilitis is a condition that causes red, swollen patches in the corners of the lips. It can be caused by infections like yeast or bacteria, nutritional deficiencies like iron or vitamin B, allergic reactions, or underlying conditions that cause dry mouth. Symptoms include red, cracked, painful skin at the corners of the mouth. Diagnosis involves examining the lesions and testing for infections or nutritional problems. Treatment focuses on treating any infections with antifungals or antibiotics, addressing nutritional deficiencies, using moisturizers, and treating underlying causes like dry mouth.
Leukoplakia is a predominantly white lesion of the oral mucosa that is characterized by thickened white patches. It is primarily linked to tobacco use and smoking is the most common cause. Leukoplakia is usually diagnosed through an oral exam and if patches look suspicious, a biopsy may be performed to check for precancerous or cancerous cells. Treatment depends on the severity and type of leukoplakia, ranging from simply monitoring the patches to surgical removal, especially if cancer is detected. Preventive measures include stopping smoking and reducing alcohol consumption.
Pemphigus vulgaris is an autoimmune disease characterized by blister formation on the skin and mucous membranes. It is caused by an antigen-antibody reaction. Symptoms include blisters in the mouth and scalp that spread and rupture, releasing fluid and causing pain. Diagnosis involves a skin biopsy and immunofluorescence testing. Treatment consists of corticosteroids, immunosuppressants like azathioprine, and biological therapies like rituximab to control the immune system and prevent blister formation. Nurses monitor patients for infection and ensure proper wound care, nutrition, and hygiene.
Geographic tongue, also known as benign migratory glossitis, is a condition that causes patches of discoloration on the tongue making it appear map-like. The patches are red with grayish-white borders where the papillae are missing. It does not cause pain but can cause numbness or tingling. The causes include genetic predisposition, stress, processed foods, spicy foods, hormonal changes, vitamin deficiencies, and allergies. It affects up to 3% of the population and is more common in females. There are no treatments but symptoms can be minimized by avoiding triggers and using over-the-counter pain relievers or mouthwashes.
This document summarizes recurrent aphthous stomatitis (canker sores). It defines the condition as recurring ulcers confined to the oral mucosa with no signs of systemic disease. It describes the three main types (minor, major, herpetiform), their clinical features, histopathology, associated syndromes, differential diagnosis, and treatments which include topical steroids, antimicrobial mouthwashes, analgesics, and intralesional steroid injections. The conclusion emphasizes that recurrent aphthous ulcers are the most common oral ulcers with three subtypes, unknown etiology, and palliative treatment of lesions.
Pemphigus is a rare autoimmune blistering disease of the skin and mucous membranes caused by antibodies against desmoglein proteins. There are three main types - pemphigus vulgaris affects the mouth and skin, pemphigus foliaceus affects the scalp and upper trunk, and paraneoplastic pemphigus is the most severe and associated with cancer. Diagnosis involves biopsy and detecting antibodies. Treatment aims to control the disease and involves high-dose corticosteroids sometimes with steroid-sparing immunosuppressants or other therapies like intravenous immunoglobulins or plasmapheresis.
Periodontal disease is a chronic bacterial infection that affects the gums and bone supporting the teeth. It ranges from gingivitis, a reversible early stage marked by red, swollen gums, to periodontitis, a more advanced stage involving irreversible bone and tissue destruction. Risk factors include smoking, diabetes, genetics, and certain medications. Symptoms include bad breath, bleeding gums, and loose teeth. Treatment involves deep cleaning below the gumline, antibiotics, and sometimes surgery to regenerate lost bone and tissue. Regular cleanings and proper brushing and flossing can help prevent periodontal disease.
This document discusses oral candidiasis, caused by the yeast Candida albicans. It presents various classifications and investigations for candidiasis, including smears, swabs, and cultures. Management involves identifying predisposing factors and using topical or systemic antifungal drugs like amphotericin B, nystatin, clotrimazole, ketoconazole, fluconazole, itraconazole or miconazole. For HIV patients, highly active antiretroviral therapy (HAART) is recommended along with antifungal drugs to treat oral candidiasis.
Dental caries is a microbiological disease that results in localized demineralization of the inorganic portion and destruction of the organic substances of the tooth. It is caused by acid produced from bacteria in dental plaque when they metabolize carbohydrates. Key factors in the development of dental caries include diet, bacteria such as Streptococcus mutans, acids, dental plaque, and time. Common sites for dental caries include pits and fissures, proximal surfaces, and cervical margins. Treatment involves reducing sugar intake, fluoride application, and properly placed restorations to prevent recurrent caries.
This document discusses oral ulceration, providing a differential diagnosis of primary and secondary ulcers. It notes that oral ulcers can be an initial presentation of systemic conditions and discusses various potential causes including infections, malignancies, drugs, trauma and dermatological conditions. Recurrent aphthous stomatitis is one of the most common causes and presents as painful ulcers that typically heal spontaneously within two weeks. Persistent or painless ulcers should be further evaluated, as they could indicate oral cancer.
Lichen planus is a chronic autoimmune disease that affects the skin and mucous membranes. It is characterized by pruritic polygonal papules and plaques that are flat topped and violaceous. The disease commonly affects middle aged women more than men. Oral lichen planus presents as white lacy lesions inside the mouth, while skin lesions typically occur on the wrists and legs. Treatment focuses on reducing symptoms through topical corticosteroids and immunosuppressants. While usually self-limiting, oral lichen planus poses a small risk of malignant transformation over the long term.
This document discusses stomatitis, an inflammation of the mouth lining. It defines stomatitis and lists its common causes such as infections, medications, nutritional deficiencies, and radiation/chemotherapy. The main signs and symptoms include pain, ulcers, and bleeding in the mouth. It describes different types of stomatitis like aphthous, angular, and denture-related stomatitis. The management involves coating agents, mouthwashes, analgesics, and topical corticosteroids to reduce inflammation and pain.
Mucocele and ranula are lesions caused by the extravasation of mucus from salivary glands into surrounding tissues. Mucoceles are commonly caused by trauma that severs or obstructs salivary ducts, allowing mucus to pool in surrounding tissues. Ranulas specifically occur on the floor of the mouth associated with sublingual or submandibular gland ducts. Histologically, they consist of mucus-filled cavities surrounded by granulation tissue and inflammatory cells. Treatment involves complete surgical excision to prevent recurrence.
Periodontitis is a chronic, slowly progressing disease which mainly results in the destruction of tooth supporting apparatus. Earlier it was classified as Chronic and Aggressive periodontitis with different clinical features and etiology. Current classification ( 2017) of periodontal disease involves periodontitis with is further divided into 4 stages and 3 grades depending on severity and rate of disease progression respectively. Diabetes meelitus and smoking are the validated risk factors for the progression of periodontitis.
Radicular cysts are the most common type of inflammatory odontogenic cyst. They form from epithelial cell rests in the jaw that become inflamed due to a non-vital tooth. There are three phases to their development: initiation from pulpal necrosis, cyst formation through proliferation of epithelial cells, and enlargement caused by osmotic pressure and bone resorption. Radicular cysts appear radiolucent on x-rays and contain fluid, non-keratinized epithelial lining, and chronic inflammatory cells. Treatment involves removal of the cyst and often extraction of the associated non-vital tooth.
Leukoplakia is a white patch or plaque that develops in the mouth and cannot be wiped away. It affects 1.5-12% of the population, usually those over age 40, and prevalence increases with age. Leukoplakia has various clinical forms and ranges in appearance from flat and uniform to raised or irregular patches. A biopsy is needed to examine the tissue for signs of dysplasia or oral cancer. While most leukoplakia is harmless, some may develop into cancer over time, so prevention focuses on lifestyle changes like quitting smoking and reducing alcohol.
Carbuncle is a skin infection caused by bacteria such as Staphylococcus and Streptococcus. It results in a painful, swollen lump under the skin that may contain pus and can develop in hairy areas. Carbuncles occur when hair follicles are infected by bacteria and involve a group of follicles. They are diagnosed through visual examination and sometimes tested fluid or blood samples. Treatment involves antibiotics, draining the carbuncle, and home remedies like warm compresses and cleaning with antibacterial soap.
This document discusses various diseases that can affect the lips. It describes conditions like angular cheilitis, lip fissures, allergic cheilitis, actinic cheilitis, exfoliative cheilitis, perioral dermatitis, lick eczema, and cheilocandidiosis. For each condition, it covers causes, symptoms, diagnosis, and management approaches. The document is intended to describe the different lip diseases that can occur so the reader understands which conditions to consider based on a patient's presentation.
Pyorrhoea, also known as periodontitis, is a bacterial infection of the gums and tissues around the teeth that leads to gum disease and tooth loss if left untreated. It is caused by a combination of factors like traumatic occlusion, poor dental hygiene, and modern diet. Symptoms include bleeding gums, bad breath, and loose teeth. Risk factors include smoking, diabetes, and poor oral hygiene. Complications of advanced pyorrhoea include tooth loss, bone destruction, and systemic infections. Home remedies and maintaining good oral hygiene through brushing and cleaning can help prevent and treat pyorrhoea.
Glossitis refers to inflammation of the tongue that causes swelling, color, and texture changes. There are two main types: acute glossitis appears suddenly with severe symptoms, while chronic glossitis recurs and may be caused by an underlying condition. People at risk include those with mouth injuries, who eat spicy foods, wear ill-fitting dentures, have herpes or immune disorders, or have low iron or food allergies. Diagnosis involves examination for mouth abnormalities and testing saliva and blood samples. Treatment consists of antibiotics if bacteria are present or topical steroids to reduce redness and soreness.
This document discusses various diseases that can affect the lips and tongue. It outlines conditions like swelling of the lips, angular chelitis, lip fissures, and perioral dermatitis that involve the lips. For the tongue, it describes abnormalities, infections like hairy tongue, traumatic injuries, geographic tongue, and median rhomboid glossitis. It provides details on symptoms, causes, and treatment approaches for many of these oral diseases.
This document provides an overview of oral manifestations of systemic diseases categorized into infectious diseases, collagen-vascular and granulomatous disorders, and fungal infections. Key points include:
- Common viral infections that can cause oral lesions include herpes simplex, herpes zoster, infectious mononucleosis, hand foot and mouth disease, measles, and mumps. Bacterial infections like tuberculosis, syphilis and leprosy can also manifest in the oral cavity.
- Collagen-vascular disorders such as Sjogren's syndrome, systemic lupus erythematosus, sarcoidosis and Wegener's granulomatosis can present with oral signs and symptoms.
- Op
Actinic chelitis, also known as actinic keratosis or solar cheliosis, is a premalignant condition of the lips caused by chronic exposure to ultraviolet radiation from sunlight. It typically affects older individuals, especially males, with fair skin who work outdoors. The lips develop scaly, thickened patches that can form fissures and crusting. If left untreated, actinic chelitis has a 10% risk of developing into squamous cell carcinoma of the lips. Treatment aims to remove or destroy the abnormal epithelium, such as with vermillionectomy or carbon dioxide laser ablation, to relieve symptoms and prevent cancer development. Long-term follow up is important after treatment due to the potential for malignant
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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This document describes normal lip anatomy and various abnormalities that may present on the lip. It discusses the importance of taking a thorough history and performing an examination to determine if a swelling is diffuse or localized, its characteristics, and any associated symptoms. Further testing may be needed to identify underlying causes or deficiencies. Common conditions mentioned include angular chelitis, perioral dermatitis, allergic cheilitis, actinic cheilitis, and mucocele. The document also reviews tongue lesions such as fissured tongue, median rhomboid glossitis, hairy tongue, and geographic tongue, emphasizing the need to consider systemic factors.
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The document provides information on various bacterial, viral, and fungal infections that can affect humans. It discusses specific infections such as actinomycosis, syphilis, tuberculosis, candidiasis, herpes simplex virus, and more. For each infection, it describes the causative agent, transmission, clinical features, histological features, and in some cases treatment. The document is an informative reference for various microbial infections.
This document discusses various lesions that can occur in the oral cavity. It begins by defining mouth ulcers and listing common causes such as physical abrasion, infection, and cancer. It then covers specific conditions like recurrent aphthous stomatitis, lichen planus, pemphigus vulgaris, and necrotizing sialometaplasia. It provides details on symptoms, appearance, epidemiology, treatment and pathogenesis for each condition. In general, the document provides a comprehensive overview of acute and chronic ulcerative lesions that can present in the oral cavity.
Mohammed Saleh's condition is actinic cheilitis, a precancerous condition caused by chronic sun exposure that damages the lips over many years. Risk factors include living in hot, dry regions, spending significant time outdoors, having fair skin, and genetic disorders like albinism or xeroderma pigmentosum. The condition begins with hyperkeratosis and solar elastosis and can progress to atrophy of the epithelium and varying degrees of dysplasia from mild to severe if left untreated.
This case report describes the diagnosis of a 65-year-old female patient with orofacial granulomatosis (OFG). The patient presented with swelling of the upper lip. An extensive diagnostic workup including biopsy and histopathological examination was performed to rule out other granulomatous conditions and confirm a diagnosis of OFG. A non-caseating granuloma was seen on biopsy. The patient responded well to intralesional corticosteroid injections but was lost to follow up. OFG is a rare disease that can mimic other conditions, making diagnosis challenging. A multidisciplinary approach including biopsy is needed to correctly diagnose and manage this condition.
Anaemia is defined as a reduction in haemoglobin, red blood cells or haematocrit below normal levels. Iron-deficiency anaemia (IDA) affects around 2 billion people worldwide. IDA is prevalent in India, affecting 20% of adult males, 40% of non-pregnant females and children, and 80% of pregnant females. IDA is classified based on its underlying cause such as reduced red blood cell production or increased destruction. Oral iron therapy is usually the first line treatment, while blood transfusions or intravenous iron may be used for more severe cases or those who cannot tolerate oral iron. The diagnosis of IDA relies on a low MCV, MCH and iron studies showing low ferritin and transferrin saturation
Atypical facial pain describes a type of chronic dull pain that may affect one or both sides of the face and is not associated with nerve distributions. It has no clear underlying cause. Management involves eliminating potential systemic or local causes, counseling, and cognitive behavioral therapy or antidepressant therapy to address pain beliefs and anxiety. Cognitive behavioral therapy aims to help patients restructure thoughts about their pain and change avoidance behaviors through relaxation, distraction, and activity.
This document discusses various types of gastric tubes including Salem sump tubes, Levin tubes, Moss Mark IV tubes, Miller-Abbott tubes, Sengstaken-Blakemore tubes, PEG tubes, and J-tubes. It provides details on their uses, placement, care, and contraindications. Guidelines are provided for enteral feeding administration and maintenance as well as parenteral nutrition indications and considerations.
The document discusses various therapeutic measures for the gastrointestinal tract including gastrointestinal intubation, tube feedings, gastrointestinal decompression, total parenteral nutrition, and peripheral parenteral nutrition. It then describes three case reports involving patients who experienced complications from enteral tube feedings including tube misplacement leading to the formation of inspissated feeding material in the esophagus.
This document provides an overview of salivary glands and saliva. It discusses the development, growth, classification and structure of major and minor salivary glands. It describes the secretion of saliva through parasympathetic and sympathetic stimulation. The document also outlines the composition and functions of saliva, as well as diseases associated with alterations in salivary secretion such as hypo-secretion and hyper-secretion. Finally, it discusses the applied diagnostic imaging and uses of saliva as a diagnostic aid.
Pemphigoid is a relatively uncommon autoimmune disease that affects the skin and oral mucosa. There are two main forms - bullous pemphigoid and mucous membrane pemphigoid. Mucous membrane pemphigoid predominantly involves oral mucosal ulceration and desquamative gingivitis. Diagnosis involves a biopsy showing subepithelial blistering and direct immunofluorescence detecting linear deposition of IgG along the basement membrane. Treatment typically involves an initial course of systemic steroids like prednisolone followed by long-term topical steroid maintenance therapy.
This presentation is all about the systemic administration of fluorides ,as it is an easier way for the administration of fluorides to prevent dental caries and tooth decay.the aim is to explain the advantages of systemic fluoride ,their present status in India and in other countries and to create awareness among population.Also raising an issue that how these methods of systemic fluoride administration can be improved so that there is better prevention of decay problems
DEVELOPMENTAL DISTURBANCES OF LIPS & PALATE / dental implant coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
This document discusses various disorders of the lips, including chelitis (inflammation of the lips). It describes different types of chelitis such as angular chelitis (at the corners of the mouth), actinic chelitis (caused by sun exposure), exfoliative chelitis (presenting with yellowish white crust), and glandular chelitis (progressive enlargement and eversion of the lower lip). It also discusses evaluation, management, and treatment options for these conditions, which may include antibiotics, antihistamines, steroids, laser therapy, or surgical procedures depending on the specific type of chelitis.
This document describes several types of lip lesions including actinic cheilitis, cheilitis glandularis, cheilitis granulomatosa, Melkersson-Rosenthal syndrome, exfoliative cheilitis, median lip fissure, double lip, and angioneurotic edema. It defines each condition, discusses their etiology, clinical features, diagnosis, differential diagnosis and treatment. The conditions range from premalignant disorders caused by sun exposure to rare inflammatory syndromes to allergic reactions that cause lip swelling. Histopathological examination aids diagnosis, while treatment depends on the specific condition but may include sun protection, steroids, surgery or antihistamines.
Children have oral mucosal conditions and other head and neck medical problems which have both similarities and differences to those found in adults .
A wide variety of oral lesions and soft tissue anomalies are detected in children, but the low frequency at which many of these entities occur makes them challenging to clinically diagnose.
This document provides information on various types of lesions and disorders that can occur on the lips. It begins with background on lip anatomy and development. It then classifies and describes different colored, ulcerative, elevated, and developmental lesions that may affect the lips. Specific disorders covered in more depth include cheilitis (inflammation of the lips), angular cheilitis, actinic cheilitis, exfoliative cheilitis, plasma cell cheilitis, and drug-induced cheilitis. Cleft lip and other congenital abnormalities are also summarized. The document provides details on causes, clinical features, diagnosis, and management for each condition.
This document discusses several oral disorders including oral hairy leukoplakia, hairy tongue, ankyloglossia, squamous cell carcinoma of the tongue, salivary gland diseases, diseases of the lips, periodontitis, dental caries, and periapical abscess. It covers the pathogenesis, clinical presentation, diagnosis and management of these conditions.
This document discusses oral candidiasis, caused by an overgrowth of Candida species in the oral cavity. It begins with an introduction to candidiasis and the most common Candida pathogens. It then covers the classification of oral candidiasis, including acute and chronic forms. Predisposing factors are discussed. The document delves into the clinical features and management of various types of oral candidiasis such as pseudomembranous candidiasis and denture stomatitis. Laboratory tests for diagnosis are also summarized, followed by an overview of antifungal drugs used to treat oral candidiasis.
This document discusses normal variations in oral mucosal color and describes common white and red lesions seen in the oral cavity. It provides details on the clinical presentation, etiology, and treatment of various conditions including leukoplakia, lichen planus, oral candidiasis, actinic cheilitis, nicotine stomatitis, geographic tongue, and lupus erythematosus. Inherited white lesions like leukoedema and white sponge nevus are also summarized, with an emphasis placed on distinguishing benign lesions from premalignant disorders.
This document summarizes oral candidiasis, including its predisposing factors, clinical presentations, investigations, treatment, and related conditions. It discusses the various forms of oral candidiasis such as pseudomembranous, atrophic, and hyperplastic candidosis. Predisposing factors include a weakened immune system, xerostomia, poor nutrition, antibiotic/radiation therapy, diabetes, and smoking. Clinical signs vary depending on the type but may include white or red lesions that can be scraped off. Treatment involves addressing predisposing factors, using topical antifungals for mild cases or systemic antifungals for more severe cases.
Cheilitis (Disorder of oral cavity) in which includes definition, causes, sig...ninamavancy321
Cheilitis is inflammation of the lips that causes symptoms like redness, swelling, dryness, and cracking. It can be caused by factors like dry weather, dehydration, infections, allergic reactions, sun exposure, and nutritional deficiencies. There are different types of cheilitis defined by their appearance and cause, such as cheilitis exfoliativa which causes continuous peeling of the outer lips. Diagnosis involves tests like biopsies, patches, and examinations. Treatment focuses on moisturizing, avoiding irritants, treating any infections with antibiotics or antifungals, and using topical steroids or ointments.
Oral manifestation of bleeding disorders and dental management of the same
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This document discusses various types of chemical injuries that can occur to orofacial structures, including allergic reactions and non-allergic reactions to drugs taken locally or systemically. It provides details on drug allergy, contact stomatitis, perioral dermatitis, angioedema, reactions to endodontic materials, bleaching agents, and systemic drugs like arsenic and bisphosphonates. Common clinical features and histopathological findings are described for each condition. Proper use and discontinuation of offending agents is emphasized for treatment and prevention of further injury.
The document discusses oral candidiasis, a common fungal infection caused by Candida species that is more prevalent in diabetics. Risk factors for diabetics include high salivary glucose levels, low saliva secretion, and impaired immune defenses. Symptoms include white patches or lesions in the mouth and throat that can cause soreness. Treatment involves antifungal medications applied topically or taken orally. Preventive measures for diabetics include controlling blood sugar, drinking water, cleaning dentures, and removing dentures at night.
Anatomy of Oral Cavity with applied anatomy.pptxAyurgyan2077
Basic anatomy of oral cavity for students of medicine and biology, this is informative slide for education purpose and for examination preparation. Describes the parts of oral cavity, right from embryonic development, muscles, blood supply and applied anatomy of those. The fun facts added make the presentation more interesting.
A concise review on some conditions that cause epithelial erosion in the oral cavity.
This presentation covers some important lesions with clear diagrams for better comprehension.
Developmental disturbances of LIP,PALATE and ORAL MUCOSAaanchalshruti
This document summarizes several developmental disturbances of the lip, palate, and oral mucosa. It describes congenital lip and commissural pits/fistulas, which can occur alone or with clefts. It also discusses Van der Woude syndrome, cleft lip and palate, cheilitis glandularis, cheilitis granulomatosa, hereditary intestinal polyposis syndrome, labial and oral melanotic macules, Fordyce's granules, and focal epithelial hyperplasia. For each condition, it provides information on etiology, clinical features, histological features if applicable, differential diagnosis, and treatment approaches.
Oral inflammatory lesions include aphthous ulcers, herpes simplex virus infections, and oral candidiasis. Aphthous ulcers are painful but self-limiting, while herpes simplex virus causes vesicles that rupture and heal without scarring. Oral candidiasis occurs when the oral microbiota is altered. Proliferative lesions like fibromas and pyogenic granulomas are reactive lesions of the oral mucosa. Leukoplakia and erythroplakia are pre-neoplastic lesions, with erythroplakia carrying a greater risk of malignant transformation. Oral squamous cell carcinoma is the most common oral cancer, often associated with tobacco and alcohol
gingiva and periodontal problems in childrenGarima Singh
This document provides an overview of gingival and periodontal diseases in children. It begins with an introduction stating that many periodontal diseases originate during childhood, so early detection and treatment are important. It then covers topics such as the normal periodontium in children, classifications of gingival diseases including gingivitis, acute gingival diseases like herpetic gingivostomatitis, and gingival enlargement. It also discusses periodontitis, specifically aggressive periodontitis which can occur in adolescents, as well as systemic diseases associated with periodontal problems. The conclusion emphasizes that early detection and treatment of periodontal issues in children can prevent more advanced diseases and also identify underlying systemic conditions.
This document summarizes guidelines for the topical treatment of psoriasis. It discusses several topical treatment options including corticosteroids, vitamin D analogues, tazarotene, tacrolimus, pimecrolimus, salicylic acid, anthralin, coal tar, and combination therapies. It provides details on the efficacy, dosing, safety and guidelines for each treatment. It also discusses when systemic therapies like methotrexate may be appropriate and provides dosing guidelines for methotrexate treatment of psoriasis.
This document summarizes information about Treponema pallidum, the causative agent of syphilis. It describes key details such as:
1. T. pallidum was discovered in 1905 by Schaudinn and Hoffmann in samples from syphilitic patients.
2. It is a thin, helically coiled bacterium that is difficult to view with conventional microscopy but can be seen with specialized staining techniques or darkfield microscopy.
3. Syphilis is diagnosed through direct visualization of T. pallidum, nontreponemal tests that detect antibodies to cardiolipins and treponemal tests that detect antibodies to T. pallidum antigens.
This document summarizes information on chronic urticaria, including its prevalence, causes, impact on quality of life, and treatment options. It notes that chronic urticaria affects approximately 1% of people with acute urticaria and has a significant negative impact on quality of life. First-line treatment includes non-sedating antihistamines, sometimes at higher off-label doses. If patients do not respond sufficiently to antihistamines alone, second-line options include doxepin, leukotriene antagonists, short-term corticosteroids, dapsone, sulfasalazine, and narrowband UVB phototherapy. The document reviews evidence on the efficacy and safety of these second-
Psoriatic arthritis is a chronic inflammatory disease that affects the joints and skin. It is characterized by osteolysis, bony proliferation, and can cause dactylitis, enthesitis, spondylitis, and various forms of arthritis. While it is classified as a type of spondyloarthritis, it is distinct from rheumatoid arthritis in that it is usually seronegative. The presentation and pattern of joint involvement in psoriatic arthritis can vary between patients and change over time, with the most common forms being asymmetrical oligoarthritis or symmetrical polyarthritis. Diagnosis is based on clinical features and classification criteria such as the CASPAR criteria.
Physiotherapy aims to preserve, enhance or restore movement and physical function impaired by disability, injury or disease. It utilizes techniques like therapeutic exercises, physical modalities, assistive devices and patient education. Physiotherapy can improve function by minimizing contractures, loss of strength and decreased skin compliance, although it may not change underlying pathology or prevent all disability. Major physiotherapy techniques include therapy using mechanical treatment, non-electric thermotherapy, electrotherapy, ozonetherapy, vacuum therapy and balneotherapy. Electrotherapy techniques like electrostimulation, ultrasound and magnetotherapy have anti-inflammatory, analgesic, spasmolytic and trophic clinical effects. Physiotherapy plays an important role in managing various conditions like wounds,
This journal club discusses targeted treatments for pruritus by reviewing recent research on the mediators and pathways involved in itch transmission. It summarizes findings on histamine receptors (especially H4), proteases/PAR-2, opioids, interleukin-31, vanilloids like capsaicin, and cannabinoids. Promising new treatments discussed include H4 antagonists, serine protease inhibitors, opioid agonists/antagonists, IL-31 antibodies, high-potency capsaicin formulations, and topical cannabinoids. These emerging therapies have potential to treat pruritus in diseases like atopic dermatitis by targeting specific components in the itch pathways.
This document discusses scar revision techniques. It begins by explaining the types of scars that can form during the wound healing process and classifications of abnormal scarring. Both non-invasive and invasive scar revision techniques are then outlined. Non-invasive options include medications, massage, silicone sheets, and lasers. Invasive techniques involve excisional procedures, grafting, and dermal augmentation using fillers or fat transfer. The timing of scar revision and factors to consider for specific scar types are also addressed.
This document summarizes methotrexate, an antimetabolite drug used to treat various conditions like psoriasis and rheumatoid arthritis. It discusses methotrexate's structure, mechanism of action, administration, indications, contraindications, dosing, monitoring guidelines, adverse effects and drug interactions. The summary describes methotrexate as a folic acid analogue that inhibits dihydrofolate reductase, interfering with DNA synthesis and having anti-inflammatory effects. It lists approved uses including psoriasis and potential off-label uses, and emphasizes monitoring blood work and liver biopsies when using long-term.
This document provides a detailed tutorial on the procedure for culturing human melanocytes. Key steps include:
1) Isolating epidermis from skin specimens using dispase enzyme solution overnight at 4°C.
2) Dispersing epidermal cells using trypsin and mechanically dissociating into a single cell suspension.
3) Seeding cells in TPA-free growth medium and incubating without disturbance for 48-72 hours.
4) Maintaining cultures by changing medium twice weekly and passaging confluent cultures using trypsin.
Methods for cryopreserving and thawing melanocytes are also described. Morphology and growth characteristics of cultured melanocytes are provided.
This document provides an overview of leprosy in India, including its transmission, diagnosis, treatment, and the national program to eliminate leprosy. Some key points:
- Leprosy primarily affects the skin, nerves, and mucous membranes and can cause deformities. It is spread through droplets and untreated patients are the main reservoir. Multi-drug therapy can cure patients and interrupt transmission.
- India's National Leprosy Elimination Program aims to integrate services, provide MDT, conduct surveillance, increase awareness, and prevent disabilities. Through these strategies, the national prevalence rate has declined and most states have achieved elimination targets.
- However, some areas still have high rates and ongoing efforts include training
Isotretinoin is a highly effective treatment for acne that works by reducing sebum production and modifying the follicular epithelium. It has immunomodulatory effects that help resolve inflammation. The document summarizes guidelines for isotretinoin use and dosing from international experts. It is recommended for severe nodular cystic acne or less severe acne that causes scarring or psychological distress. Low-dose and intermittent dosing regimens can be effective with fewer side effects. Precautions are needed in women of childbearing age due to teratogenicity. Isotretinoin provides long-term remission and is beneficial as early treatment to prevent scarring.
This document summarizes information about gonorrhea (Neisseria gonorrhoeae), including:
1. The history of gonorrhea identification and treatment, from ancient Greek beliefs to the development of antibiotics and culture techniques in the 19th-20th centuries.
2. Details on the pathogenesis, clinical manifestations, diagnosis, and treatment of common and complicated gonorrheal infections affecting the urethra, cervix, rectum, pharynx, and other sites.
3. Descriptions of local complications like epididymitis and pelvic inflammatory disease, and systemic complications including disseminated gonococcal infection.
This document summarizes an approach to diagnosing and treating cases of genital ulcers. It begins with definitions of genital ulcers and their etiologies, which can be sexually transmitted or non-sexually transmitted infections. It then describes three approaches: traditional clinical, laboratory-assisted, and syndromic management. The syndromic management approach diagnoses based on symptoms and signs and treats for the most common causes. Advantages include being fast, effective, inexpensive and allowing single-dose treatment. Limitations include potential over-treatment. Guidelines for taking history, examination, investigations, and treating common causes like herpes, syphilis, chancroid, and donovanosis are provided.
Approach to a case of diffuse hair loss in females
. Anagen effluvium-
(a)Dystrophic
(b)Loose anagen hair
2. Telogen effluvium –
(a)acute telogen effluvium
(b)Chronic telogen effluvium
3. Female pattern hair loss
Primary CTE –represents a primary disorder and is a diagnosis of exclusion.
Secondary CTE- secondary to variety of systemic disorders.
Iron deficiency
Other deficiency –protein calorie malnutrition ,zinc deficiency
Thyroid diseases
Metabolic diseases-chronic liver or renal failure, advanced malignancy, pancreatic disease and upper GI disorder with malabsorption
SLE and other connective tissue disorders.
HIV infection
Drug induced
This seminar presentation discusses the uses of dapsone, colchicine, and thalidomide in dermatology. For dapsone, it provides a detailed history, mechanisms of action, indications, dosing, administration, and adverse effects. It is commonly used to treat dermatitis herpetiformis, leprosy, and other chronic inflammatory dermatoses. For colchicine, it discusses the mechanisms of action, pharmacokinetics, and various dermatological uses including papulosquamous dermatoses, recurrent aphthous stomatitis, Behcet's syndrome, bullous diseases, vasculitis, and others. Adverse effects include gastrointestinal issues and bone marrow
This document discusses various cutaneous manifestations of endocrine diseases. It covers skin symptoms of diabetes mellitus including diabetic microangiopathy, which can cause conditions like erysipelas-like erythema and wet gangrene of the foot. It also discusses diabetic neuropathy and its associated symptoms. Further, it discusses cutaneous features of thyroid diseases including hypothyroidism and thyrotoxicosis, as well as associated autoimmune conditions. Finally, it briefly covers skin conditions related to pituitary disorders like acromegaly and gigantism seen in hyperpituitarism.
This document discusses cutaneous pseudolymphoma (CPL). It was first described in 1891 and has been called by various names over time. Pseudolymphoma clinically and sometimes histologically mimics lymphoma, but has benign behavior and does not meet criteria for malignant lymphoma. It is characterized by lymphocytic infiltration in the skin in response to stimuli. CPL is classified into types depending on the predominant cell type (B cell vs T cell) and location of infiltration (nodular vs stripe-like). While CPL has no associated mortality, localized variants can cause minor symptoms. Treatment involves excision, corticosteroids, radiation therapy, and immunosuppressants depending on the subtype.
Plato and Aristotle's Views on Poetry by V.Jesinthal Maryjessintv
PPT on Plato and Aristotle's Views on Poetry prepared by Mrs.V.Jesinthal Mary, Dept of English and Foreign Languages(EFL),SRMIST Science and Humanities ,Ramapuram,Chennai-600089
This is an introduction to Google Productivity Tools for office and personal use in a Your Skill Boost Masterclass by the Excellence Foundation for South Sudan on Saturday 13 and Sunday 14 July 2024. The PDF talks about various Google services like Google search, Google maps, Android OS, YouTube, and desktop applications.
PRESS RELEASE - UNIVERSITY OF GHANA, JULY 16, 2024.pdfnservice241
The University of Ghana has launched a new vision and strategic plan, which will focus on transforming lives and societies through unparalleled scholarship, innovation, and result-oriented discoveries.
Topics to be Covered
Beginning of Pedagogy
What is Pedagogy?
Definition of Pedagogy
Features of Pedagogy
What Is Pedagogy In Teaching?
What Is Teacher Pedagogy?
What Is The Pedagogy Approach?
What are Pedagogy Approaches?
Teaching and Learning Pedagogical approaches?
Importance of Pedagogy in Teaching & Learning
Role of Pedagogy in Effective Learning
Pedagogy Impact on Learner
Pedagogical Skills
10 Innovative Learning Strategies For Modern Pedagogy
Types of Pedagogy
2. •
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Synonym- Inflammation of the lips
May arise as a
Primary disorder of the vermilion zone or
Inflammation may extend from nearby skin or,
Less often, from the oral mucosa
3. Causes of cheilitis.
Chapping due to cold and wind
Actinic prurigo of the lip
Eczematous cheilitis
Glandular cheilitis
Contact cheilitis
Granulomatous cheilitis
Drug-induced cheilitis
Exfoliative (factitious) cheilitis
Infective cheilitis
Plasma cell cheilitis
Angular cheilitis
Nutritional cheilitis
Ultraviolet irradiation
Dermatoses
Actinic cheilitis
Trauma
4. ‘Chapping’ of the lips
• Reaction to adverse environmental
conditions
• Caused by exposure to freezing cold or to
hot dry winds.
• Keratin of the vermilion loses its
plasticity, so that the lips become sore,
cracked and scaly.
• Affected person tends to lick the lips, or
to pick at the scales, which may
aggravate the condition.
• Treatment- Petroleum jelly and avoidance
of the adverse environmental conditions
5. Eczematous cheilitis
• Presenting as redness with
dryness, scaling and fissuring.
• Major causes- atopic
dermatitis and irritant or
allergic contact reactions
• Treatment- Emollients and
topical corticosteroids.
• A potent steroid may be
required to bring the
condition under control
6. Contact cheilitis
• F>M
• Affect all age groups, but adults>children.
• Lip cosmetics are the most common allergen source in
women, and toothpastes in men.
• Medications in the elderly.
• Dental materials and oral hygiene products in all age
groups.
• Reactions to food mainly affect children.
• Patients are often also atopic.
7. • Major sources of allergens :
• Lipsticks and other lip cosmetics including sunscreens
• Toothpaste and other dental care products (mouthwash,
denture cleaner, dental floss, toothpicks)
• Metals – dental restorations, orthodontic devices, musical
instruments, metal casings of lip cosmetics, habitual
sucking of metal objects
• Food, Medications, Nail varnishes
• Rubber/latex gloves
• Common allergen groups:
• Metals such as nickel
• Fragrance/Flavourings and Preservatives
8. • C/f- Lipstick cheilitis may confined to the vermilion or
extends beyond.
• Persistent irritation and scaling or a more acute reaction
with oedema and vesiculation.
• Other forms of cheilitis vary greatly in their clinical
appearance.
• Foods commonly also involve the skin around the mouth.
• If a small, sucked object is responsible, the reaction may be
confined to one part of the lips
9. • Diagnosis- If acute eczematous changes- contact cheilitis .
• If the changes are confined to irritation and scalingexfoliative cheilitis must be excluded.
• If an allergic reaction is suspected, patch tests should be
carried out.
• Treatment- Topical corticosteroids will give symptomatic
relief but the offending substance must be identified and
avoided
10. Infective cheilitis
• Viral- HSV are common, and VZV and HPV may also affect
the lips.
• Bacterial- Dental infection or occasionally a furuncle or
carbuncle may cause swelling of the lip.
• Impetigo may mimic herpes labialis.
• Lip is the MC extragenital site for a primary syphilitic lesion.
• Most lip chancres in males tend to occur on the upper lip,
in females on the lower lip.
11. • In secondary syphilis, moist, flat, papulonodular lesions
(condylomata lata) often appear at the mucocutaneous
junctions and commissures.
• TB or leprosy may cause chronic lip swelling or ulceration
• Rhinoscleroma initially affects the nasal mucosa but may
spread slowly to the upper lip, producing plaques or
nodules with sunken centres.
• Extreme hardness of the infiltrations is characteristic.
12. • Protozoal- Cutaneous or mucocutaneous leishmaniasis
typically causes swellings on the upper lip with later
enlargement and destruction of the lip, reflecting the three
stages of oedema, granulomatous proliferation and then
necrosis.
• Fungal- Blastomycosis and paracoccidioidomycosis are
uncommon causes of chronic ulceration affecting the lip,
producing very similar clinical lesions to leishmaniasis.
• Others- Red swollen lips with fissuring and exfoliation are
prominent in mucocutaneous lymph node syndrome
(Kawasaki disease).
13. Angular cheilitis
Synonym-Angular stomatitis
• Acute or chronic inflammation of the skin and contiguous
labial mucous membrane at the angles of the mouth.
• Aetiology• Dribble of saliva causing eczematous cheiltiis, a form
of contact irritant dermatitis
• Overhang of upper lip resulting in deep furrows
(marionette lines)
• Dry chapped lips
• Proliferation of bacteria (impetigo), yeasts (thrush) or virus
(cold sores)
14. • Affects children and adults, in poor health.
• Predisposing factors include:
• Oral thrush: infancy, old age, diabetes, systemic
corticosteroid or antibiotic use
• Dentures, especially if they are poor fitting, and there is
associated gum recession
• Poor nutrition: coeliac disease, iron deficiency, riboflavin
deficiency
• Systemic illness, particularly IBD (ulcerative colitis
and Crohn disease)
• Sensitive skin, especially atopic dermatitis
• Genetic predisposition, for example in Down syndrome
• Oral retinoid
15. •
•
•
•
•
•
•
•
•
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C/fPainful cracks / fissures
Blisters / erosions / ooze / crusting
Redness, Bleeding
It may progress to more widespread impetigo or candidal
skin infection on the adjacent skin and elsewhere.
Investigations
Culture of swabs taken from the corners of the mouth may
reveal:
Candida albicans
Staphylococcus aureus
Herpes simplex
17. •
•
•
•
•
•
•
•
•
TreatmentLip balm or thick emollient ointment, applied frequently
Topical antiseptics
Topical or oral antibiotic
Topical antifungal cream
Oral antifungal medication
Topical steroid ointment
Nutritional supplements
Filler injections or implants to build up the oral
commissures
18. Actinic cheilitis
• Synonyms-Actinic keratosis of lip • Solar cheilosis
• Aetiology- MC in hot dry regions, in outdoor workers and in
fair-skinned people (skin types I and II).
• Vermilion of the lower lip receives a high dose of UV
irradiation because it is almost at right angles to the rays of
the midday sun and is poorly protected by keratin and
melanocytes.
19. •
•
•
•
•
C/f- Dry lips, Thinned skin of the lips, Scaly patches
Less common features:
Swelling of the lip
Redness and soreness, Ulceration and crusting
Loss of demarcation between the vermilion border of the
lip and its adjacent skin
• Prominent folds and lip lines
• White thickened patches (leukokeratosis)
• Discoloured skin with pale or yellow areas
21. • Treatment- to relieve symptoms and to prevent
development of SCC
• Topical agents: 5% fluorouracil TDS for 10 days is suitable.
• Tretinoin, TCA or diclofenac gel may also be effective.
• Vermilionectomy (lip shave).
• Laser ablation.
• Photodynamic therapy.
• Following treatment, prevention of recurrence by the
regular use of a sunscreen lipsalve containing paminobenzoic acid probably gives the best protection.
22. Glandular cheilitis
• Inflammatory changes and swelling of salivary glands in the
lips.
• Aetiology- idiopathic, few cases familial.
• Excessive salivary secretion from minor salivary glands, an
unusual clinical response to irritation of the lip from some
other cause such as actinic damage or repeated licking.
• C/f- Lower lip is slightly thickened and bears numerous
pinhead-sized orifices, from which mucous saliva can readily
be squeezed.
• Upper lip is rarely involved
• In the more severe suppurative form (Volkmann’s cheilitis) the
lip is considerably and permanently enlarged, and subject to
episodes of pain, tenderness and increased enlargement.
23. • Surface is covered by crusts and
scales, beneath which the
salivary duct orifices may be
discovered.
• In the most severe forms there
may be deep-seated infection
with abscess formation and
fistulous tracts.
• In some series 20–30% of cases
progress to SCC.
• In many cases it is a
consequence of actinic cheilitis.
• T/t- If the lips are grossly
enlarged, excision of an
elongated ellipse of tissue may
be required
24. Granulomatous cheilitis
• Lumpy swelling of the lips.
• Different causes, such as allergy, Crohn disease, sarcoidosis
and orofacial granulomatosis.
• Rare causes are infections, cancers and genetic disorders.
• Miescher-Melkersson-Rosenthal syndrome refers to
recurrent chronic swelling and enlargement of one or both
lips.
• Facial palsy and fissuring of the tongue may also occur.
• Cause- not known, but genetics may have a role.
• In Miescher cheilitis, the changes are confined to the lip.
• First symptom is a sudden swelling of the upper lip.
25. • Swelling of the lower lip and one or both cheeks may follow in
Melkersson-Rosenthal syndrome.
• Less commonly, the forehead, eyelids, or one side of the scalp
may be involved.
• Swelling may feel soft, firm or nodular when touched.
• Recurrent attacks may occur within days or even years after
the first episode.
• At each episode the swelling may become larger, more
persistent and eventually become permanent.
• At this time the lips may crack, bleed and heal leaving a
reddish-brown colour with scaling. This can be painful.
• Eventually the lip takes on the consistency of hard rubber.
26. •
•
•
•
•
Other symptoms include:
Fever, headache and visual disturbances
Mild enlargement of regional lymph nodes in 50% of cases.
Fissured or plicated tongue in 20-40% of cases.
Facial palsy; intermittent, then possibly permanent and can
be unilateral or bilateral, and partial or complete.
• It occurs in about 30% of cases.
• Skin biopsy of the affected tissue shows characteristic
granulomas i.e. a mixed inflammatory cell infiltration in the
dermis.
28. • Treatment- Reactions to dietary components should be
sought and possible antigens avoided.
• Topical corticosteroids
• Long term anti-inflammatory antibiotics e.g. a six to twelve
month course of tetracycline, erythromycin or penicillin
• Corticosteroids injected into the lips to reduce swelling.
Injections need to be repeated every few months.
• NSAIDS
• Mast cell stabilisers eg ketotifen
• Clofazimine
• Sulfasalazine
• Surgical reduction
29. Exfoliative cheilitis
• Presenting as continuous peeling of the lips.
• Factitial- if the behaviour triggering the condition is
attention-seeking.
• Exfoliative - obsessive-compulsive with no intent of gain.
• Mainly affects young adults <30 years with personality
disorders.
• Initiating factors include: Mouth breathing, Lip licking, Lip
sucking, Lip picking, Lip biting.
• Poor oral hygiene, HIV infection and Candida.
30. • C/f- Continuous peeling of the vermilion of the lips.
• Usually affect the lower lip.
• Peeling appears to be cyclical and proceeds at different
rates in different sites, so there is always some part of the
lip peeling at any time.
• There may be associated bleeding resulting in formation of
a haemorrhagic crust.
• Condition may be painful, causing difficulty in eating and
speaking.
• Other symptoms include sensations of: Tingling, Itch,
Dryness, Ulceration or fissuring may occur
33. • Diagnosis- it is a diagnosis of exclusion and there is no
specific diagnostic test for it.
• A careful psychiatric assessment can be especially helpful
• Treatment- Some cases resolve spontaneously or with
improved oral hygiene.
• Reassurance and topical corticosteroids, or tacrolimus may
be helpful in some cases but others require psychotherapy,
antidepressants or tranquillizers.
34. Plasma cell cheilitis
• Uncommon chronic
inflammatory dermatitis that
presents with flat to slightly
elevated erosive erythematous
plaques.
• Genital areas are often
involved, k/a plasma cell
balanitis or vulvitis.
• Sometimes resistant to
conventional topical
corticosteroid therapy
• Recent reports show that
topical calcineurin inhibitors
are effective
35. Lupus erythematosus
• Involvement of the vermilion
zone is quite common in both DLE
and SLE.
• DLE can be premalignant, and
should be treated vigorously with
topical steroid ointments and
sunscreens.
• Cheilitis of SLE more severe, with
erosions and haemorrhagic
crusts.
• Lupus erythematosus can be very
difficult to distinguish from LP of
the lips, both clinically and by
histology
37. • Possible fruit and vegetable allergens.
Apple
Fennel
Asparagus
Artichoke
Carrot
Cherry
Orange
Peach
Pear
Lime
Parsley
Onion
Garlic
Parsnip
Mango
Celery
Potato
Tomato
Pineapple
Plum
Banana
38. Miscellaneous objects-
Metal hair clips
metal pencils
cobalt paint on blue pencils
nail varnish
Wooden
nickel and reed mouthpieces
of musical instruments
39. Lipsticks and lipsalves
mineral oils and wax
oleyl alcohol
castor oil
azulene
lanolin
sesame oil
preservatives,
stearates
perfumes
colophony
colours
eosin
azo dyes
Sunscreens (e.g. cinnamic aldehyde)
41. • It is present from birth in some, which may indicate genetic
susceptibility.
• There may be loss of sense of taste and decreased salivary
gland secretion.
• Regional lymph nodes are enlarged in 50% of cases but not
usually very greatly.
• Facial palsy of the lower motor neurone type occurs in
some 30% of cases.
• It may precede the attacks of oedema by months or years,
but more commonly develops later Although intermittent
at first, the palsy may become permanent.
42. • It may be unilateral or bilateral, and partial or complete.
• Other cranial nerves (olfactory, auditory, glossopharyngeal
and hypoglossal) may occasionally be involved.
• Involvement of the CNS has also been reported, but the
significance of the resulting symptoms is easily overlooked
as they are very variable, sometimes simulating
disseminated sclerosis but often with a poorly defined
association of psychotic and neurological features.
• Autonomic disturbances may occur.
43. • Diagnosis- Essential feature of the syndrome is the
granulomatous swelling of lip or face.
• In the early attacks clinical differentiation from angiooedema may be impossible in the absence of either scrotal
tongue or facial palsy.
• Persistence of the swelling between attacks should suggest
the diagnosis, which can sometimes be confirmed by
biopsy.
• In established cases, other causes of macrocheilia must be
excluded.
• Lymphoma is a rare differential diagnosis.
44. Actinic prurigo
• Familial photodermatitis, Seen in High altitude especially in
Latin America, and in China.
• Young women presents as a photosensitive facial rash with
pruritic lower lip cheilitis,
• May be a/w conjunctivitis, eyebrow alopecia and pterygion.
• Distinguished from actinic cheilitis, which is due to
prolonged and excessive exposure to UV irradiation.
• PMLE is almost invariably present in the actinic prurigo of
native Americans.
• Treatment- Sunscreens, β-carotene, PUVA, and
antihistamines.
• Oral thalidomide may be tried