- (1997) Print ad (with Matthew Perry): Microsoft.
- (1997) TV commercial: Lynx deodorant.
- (1997) TV commercial: L'Oréal Elvive shampoo.
- NBC-TV Stay-in-School promo: The More You Know, where her reason is "Smarter is sexier than stupid any day."
- (1995) Print ad: "Got Milk?" campaign (with Lisa Kudrow).
- (1996) Music video: Appeared in Tom Petty & The Heartbreakers video "Walls".
- (1998) TV commercial: L'Oréal Elnett hairspray.
- (1994) Appeared, with her Friends (1994) castmates, in the music video for The Rembrandts' single "I'll Be There For You".
- (2001) Music video: Appeared in Melissa Etheridge's "I Want To Be In Love" video.
- (2002) Print ad: Damiani jewelry.
- (2001) TV commercial: Heineken beer.
- (2006) Was interviewed in an episode of Talking Movies (1999) about the 2006 Sundance Film Festival. The other interviewees were Josh Hartnett, Shia LaBeouf (as Shia La Boeuf) and Chris Gorak.
- (12/13/88-1/22/89) stage: Appeared in Off-Broadway production of "For Dear Life".
- (2007, 2010-11, 2016-17) Print ads: Glacéau's Smart Water. New for 2016-2017: "running mate. vapor-distilled for purity, electrolytes for taste." Frequently on magazine back covers, including September 1, 2017 back cover of "Entertainment Weekly."
- Stage: Appeared in "We Interrupt This Program", Tiffany Theater, Los Angeles.
- (2007) Public Service Announcement (PSA) TV commercials: St. Jude's Childrens Research Hospital.
- Stage: Appeared in off-Broadway production of "Dancing on Checker's Grave".
- (2001) Unsold pilot: Executive producer of a comedy pilot based on Gary Goldstein's stage play, "Parental Discretion".
- (1980) When she was 11, a painting she had done was displayed in the Metropolitan Museum of Art.
- (2013) TV commercials: Aveeno Positively Radiant daily moisturizer.
- (2013-14) Print ads: Living Proof, a line of high-end hair care products; she was, for a short time, a part owner of the company .
- (2013- Print ads: Aveeno Active Naturals lotion and sunscreen.
- (10/2013) Print ads: Women's Cancer Research Fund and Saks Fifth Avenue.
- (1/7/13) It was publicly announced that she was named the commercial spokesperson and new face of Aveeno. The "New York Post" said that she would earn "eight figures" for the contract.
- (2015) Print ads: Aveeno's Positively Radiant daily moisturizer and skin scrub.
- (11/14-12/14) TV commercial: "It's Not a Toy They Want," with Jennifer Aniston, Michael Strahan, Jon Hamm, Sofía Vergara, and Marlo Thomas, for St. Jude Children's Research Hospital and stjude.org.
- (2015) TV commercial: "Nightmare," for Emirates A380 First Class Private Suite service, Lie Flat Business Class services, and Shower Spa service from Emirates Airlines.
- (2015) Web video: on emirates.com/us/english/ for Emirates Airlines US customers.
- (2016-17) Series of TV commercials, "My Friends, It's All About eyelove," and having a chat with your eye doctor about your dry eyes, from Shire Pharmaceuticals.
- (2016) TV commercial: Beauty Sleep," for Absolutely Ageless Restorative Night Cream, Absolutely Ageless Daily Moisturizer, Absolutely Ageless Intensive Renewal Serum, Absolutely Ageless Nourishing Cleanser, and Absolutely Ageless Eye Cream from Aveeno.
- (2016) TV commercial: "Blackberry Complex," for Absolutely Ageless Restorative Night Cream, Absolutely Ageless Collection, Absolutely Ageless Daily Moisturizer, Absolutely Ageless Intensive Renewal Serum, and Absolutely Ageless Nourishing Cleanser from Aveeno.
- (2017) TV commercial: "60 Seconds," for Positively Radiant 60-Second In-Shower Facial Cleanser from Aveeno.
- (2013) TV commercial: "Hydration," for Daily Moisturizing Lotion from Aveeno.
- (2015) TV commercial: "Feather Light," for Daily Moisturizing Sheer Hydration Lotion from Aveeno.
- (2018) TV commercial: "Lightweight," for Positively Radiant Sheer Daily Moisturizer from Aveeno.
- (2014) TV commercial: "Naturally Beautiful Results," for Daily Moisturizing Lotion from Aveeno.
- (2019) TV commercial: "Skin Happy," for Daily Moisturizing Lotion from Aveeno.
- (2015) TV commercial: "Eat Well, Live Well, and Be Healthy," for Daily Moisturizing Lotion from Aveeno.
- (2015) TV commercial: "Positive Attitude," for Positively Radiant Daily Moisturizer and Positively Radiant Makeup Removing Wipes from Aveeno.
- (2014) TV commercial: "Reducing the Look of Brown Spots,?" for Positively Radiant Targeted Tone Corrector from Aveeno.
- (2014) TV commercial: "Naturally Beautiful Results," for Positively Radiant Daily Moisturizer. from Aveeno.
- (9/20-10/20) TV commercial: "The Aveeno Principle Scientist," for Positively Radiant Daily Moisturizer from Aveeno.
- (2016) Internet/Social Media (Facebook, YouTube) for Positively Mineral Sunscreen from Aveeno.
- (2013) TV commercial: "Spots," for Positively Radiant from Aveeno.
- (2021) TV commercials: Living Protein collagen.
- (2023) TV commercial for Pvolve exercise program.
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