Serum (blood)

Preparation of serum cups for a lipids panel designed to test cholesterol levels in a patient’s blood

In blood, the serum (UK /ˈsɪərəm/ or US /ˈsɪrəm/) is the component that is neither a blood cell (serum does not contain white or red blood cells) nor a clotting factor; it is the blood plasma with the fibrinogens removed. Serum includes all proteins not used in blood clotting (coagulation) and all the electrolytes, antibodies, antigens, hormones, and any exogenous substances (e.g., drugs and microorganisms).

A study of serum is serology, and may also include proteomics. Serum is used in numerous diagnostic tests, as well as in blood typing.

Blood is centrifuged to remove cellular components. Anti-coagulated blood yields plasma containing fibrinogen and clotting factors. Coagulated blood (clotted blood) yields serum without fibrinogen, although some clotting factors remain.

Serum is an essential factor for the self-renewal of embryonic stem cells in combination with the cytokine leukemia inhibitory factor.

See also

• Albumin
• Globulin
• Human serum albumin
• Lipid
• Serum iron
• Serum protein electrophoresis
• Serum total protein

References

• Martin, Elizabeth A., ed. (2007). Concise Medical Dictionary (7th ed.). Oxford, England: Oxford University Press. ISBN 0-19-280697-1. Retrieved 8 September 2009. 
• Wang, Wendy; Srivastava, Sudhir (2002). "Serological Markers". In Lester Breslow. Encyclopedia of Public Health 4. New York, New York: Macmillan Reference USA. pp. 1088–1090. 

External links

• Blood