Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.[1] CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle.[2]
^ abFu, T J; Peng J, Lee G, Price D H, Flores O (December 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". J. Biol. Chem. (UNITED STATES) 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. ISSN0021-9258. PMID10574912.Cite uses deprecated parameters (help)
^ abDe Falco, G; Bagella L, Claudio P P, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A (January 2000). "Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation". Oncogene (ENGLAND) 19 (3): 373–9. doi:10.1038/sj.onc.1203305. ISSN0950-9232. PMID10656684.Cite uses deprecated parameters (help)
^Simone, Cristiano; Bagella Luigi, Bellan Cristiana, Giordano Antonio (June 2002). "Physical interaction between pRb and cdk9/cyclinT2 complex". Oncogene (England) 21 (26): 4158–65. doi:10.1038/sj.onc.1205511. ISSN0950-9232. PMID12037672.Cite uses deprecated parameters (help)
^Lee, D K; Duan H O, Chang C (March 2001). "Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation". J. Biol. Chem. (United States) 276 (13): 9978–84. doi:10.1074/jbc.M002285200. ISSN0021-9258. PMID11266437.Cite uses deprecated parameters (help)
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator.". IUBMB Life51 (3): 175–81. doi:10.1080/152165401753544241. PMID11547919.
Huigen MC, Kamp W, Nottet HS (2004). "Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection.". Eur. J. Clin. Invest.34 (1): 57–66. doi:10.1111/j.1365-2362.2004.01282.x. PMID14984439.
Rice AP, Herrmann CH (2004). "Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages.". Curr. HIV Res.1 (4): 395–404. doi:10.2174/1570162033485159. PMID15049426.
Minghetti L, Visentin S, Patrizio M, et al. (2004). "Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions.". Neurochem. Res.29 (5): 965–78. doi:10.1023/B:NERE.0000021241.90133.89. PMID15139295.
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Bannwarth S, Gatignol A (2005). "HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.". Curr. HIV Res.3 (1): 61–71. doi:10.2174/1570162052772924. PMID15638724.
Gibellini D, Vitone F, Schiavone P, Re MC (2005). "HIV-1 tat protein and cell proliferation and survival: a brief review.". New Microbiol.28 (2): 95–109. PMID16035254.
Peruzzi F (2006). "The multiple functions of HIV-1 Tat: proliferation versus apoptosis.". Front. Biosci.11: 708–17. doi:10.2741/1829. PMID16146763.